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osbp2b oxysterol binding protein 2b [ Danio rerio (zebrafish) ]

Gene ID: 561797, updated on 2-Nov-2024

Summary

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Official Symbol
osbp2bprovided by ZNC
Official Full Name
oxysterol binding protein 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060526-3
See related
Ensembl:ENSDARG00000022772 AllianceGenome:ZFIN:ZDB-GENE-060526-3
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-106a19.1
Summary
Predicted to enable cholesterol binding activity. Predicted to act upstream of or within lipid transport. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Is expressed in telencephalon. Orthologous to human OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See osbp2b in Genome Data Viewer
Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24570150..24712386, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (24066350..24208702, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene ATPase H+ transporting V0 subunit a2b Neighboring gene si:dkey-90a24.1 Neighboring gene RAS-like, family 10, member A Neighboring gene adaptor related protein complex 1 subunit beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC561797

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122748.1 → NP_001116220.1  uncharacterized protein LOC561797

    Status: PREDICTED

    Source sequence(s)
    BX088551, BX537282, CR381680
    UniProtKB/TrEMBL
    A0A8N7UYU0, A2BEG1
    Related
    ENSDARP00000038117.5, ENSDART00000033630.6
    Conserved Domains (3) summary
    cd13284
    Location:73 → 168
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam00169
    Location:72 → 162
    PH; PH domain
    pfam01237
    Location:418 → 788
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    24570150..24712386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476216.2 → XP_021331891.1  uncharacterized protein LOC561797 isoform X1

    UniProtKB/TrEMBL
    A0A8M9Q8S0
    Conserved Domains (2) summary
    cd13284
    Location:73 → 168
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:432 → 802
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_068221228.1 → XP_068077329.1  uncharacterized protein LOC561797 isoform X2

  3. XM_009301313.4 → XP_009299588.1  uncharacterized protein LOC561797 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AS31
    Conserved Domains (1) summary
    pfam01237
    Location:165 → 535
    Oxysterol_BP; Oxysterol-binding protein

  4. XM_021476217.2 → XP_021331892.1  uncharacterized protein LOC561797 isoform X3

    UniProtKB/TrEMBL
    A0A8M9PKA3
    Conserved Domains (1) summary
    pfam01237
    Location:318 → 688
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. XR_002458776.2 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394576.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    271283..376833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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