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kif22 kinesin family member 22 [ Danio rerio (zebrafish) ]

Gene ID: 561788, updated on 2-Nov-2024

Summary

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Official Symbol
kif22provided by ZNC
Official Full Name
kinesin family member 22provided by ZNC
Primary source
ZFIN:ZDB-GENE-080204-34
See related
Ensembl:ENSDARG00000102624 AllianceGenome:ZFIN:ZDB-GENE-080204-34
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171724
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including central nervous system development; somitogenesis; and thigmotaxis. Predicted to be located in cytoskeleton and nucleus. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in brain. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 2. Orthologous to human KIF22 (kinesin family member 22). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See kif22 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (5048074..5071836)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (5013117..5036879)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family M (with RUN domain) member 1 Neighboring gene Rho GTPase activating protein 27 Neighboring gene small nucleolar RNA SNORA30/SNORA37 family Neighboring gene small nucleolar RNA SNORA30/SNORA37 family Neighboring gene small nucleolar RNA SNORA30/SNORA37 family Neighboring gene proline-rich transmembrane protein 2 Neighboring gene centrosomal protein 55 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of zebrafish Esrom (Myc-binding protein 2) RCC1-like domain splice variants. Wang H. Mol Cell Biochem, 2010 Jun. PMID 20143133
  2. Reversible neuronal and muscular toxicity of caffeine in developing vertebrates. Rodriguez RS, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2014 Jun. PMID 24667760
  3. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. McCammon JM, et al. Hum Mol Genet, 2017 Oct 1. PMID 28934389, Free PMC Article
  4. Zebrafish homologs of genes within 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Blaker-Lee A, et al. Dis Model Mech, 2012 Nov. PMID 22566537, Free PMC Article
  5. Comparative transcriptome analysis of heat-induced domesticated zebrafish during gonadal differentiation. Wang C, et al. BMC Genom Data, 2022 May 31. PMID 35641933, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within somitogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thigmotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF22
Names
zKIF22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113591.1 → NP_001107063.1  kinesin-like protein KIF22

    See identical proteins and their annotated locations for NP_001107063.1

    Status: PROVISIONAL

    Source sequence(s)
    BC154464
    UniProtKB/Swiss-Prot
    A8WFU8
    Related
    ENSDARP00000137572.1, ENSDART00000172607.2
    Conserved Domains (3) summary
    smart00129
    Location:19 → 351
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01376
    Location:19 → 343
    KISc_KID_like; Kinesin motor domain, KIF22/Kid-like subgroup
    pfam12836
    Location:571 → 620
    HHH_3; Helix-hairpin-helix motif

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    5048074..5071836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8WFU8.1 GenPept UniProtKB/Swiss-Prot:A8WFU8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.