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csnk1g2b casein kinase 1, gamma 2b [ Danio rerio (zebrafish) ]

Gene ID: 561724, updated on 19-Jun-2024

Summary

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Official Symbol
csnk1g2bprovided by ZNC
Official Full Name
casein kinase 1, gamma 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-285
See related
Ensembl:ENSDARG00000034056 AllianceGenome:ZFIN:ZDB-GENE-060825-285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153415
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See csnk1g2b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (20495902..20559956)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (20463804..20527871)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene REX1, RNA exonuclease 1 homolog Neighboring gene diencephalon/mesencephalon homeobox 2 Neighboring gene major facilitator superfamily domain containing 12b Neighboring gene nuclear factor I/C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The CK1 gene family: expression patterning in zebrafish development. Albornoz A, et al. Biol Res, 2007. PMID 18064361
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153415

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase 1, gamma 2b; casein kinase I isoform gamma-3
NP_001039315.1
NP_001277265.1
XP_005166916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045850.2 → NP_001039315.1  casein kinase I isoform gamma-3 isoform 1

    See identical proteins and their annotated locations for NP_001039315.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BX323082
    UniProtKB/TrEMBL
    B2GPY9, Q0P446
    Related
    ENSDARP00000091101.3, ENSDART00000100328.4
    Conserved Domains (3) summary
    COG0515
    Location:42 → 411
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 403
    CK1gamma_C; Casein kinase 1 gamma C terminal

  2. NM_001290336.1 → NP_001277265.1  casein kinase I isoform gamma-3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BX323082
    UniProtKB/TrEMBL
    A0A8M1P0J7, B0S603
    Related
    ENSDARP00000012086.8, ENSDART00000021683.10
    Conserved Domains (3) summary
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam00069
    Location:43 → 300
    Pkinase; Protein kinase domain
    pfam12605
    Location:329 → 369
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    20495902..20559956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166859.4 → XP_005166916.1  casein kinase 1, gamma 2b isoform X1

    See identical proteins and their annotated locations for XP_005166916.1

    UniProtKB/TrEMBL
    B2GPY9, Q0P446
    Conserved Domains (3) summary
    COG0515
    Location:42 → 411
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14126
    Location:42 → 329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:329 → 403
    CK1gamma_C; Casein kinase 1 gamma C terminal

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394719.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    6677..72982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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