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nars2 asparaginyl-tRNA synthetase 2, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 561673, updated on 2-Nov-2024

Summary

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Official Symbol
nars2provided by ZNC
Official Full Name
asparaginyl-tRNA synthetase 2, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060929-596
See related
Ensembl:ENSDARG00000098441 AllianceGenome:ZFIN:ZDB-GENE-060929-596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:153218
Summary
Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in mitochondrion. Is expressed in female organism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 94 and combined oxidative phosphorylation deficiency 24. Orthologous to human NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See nars2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (9601641..9631592, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (9625575..9655521, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene sacsin molecular chaperone Neighboring gene uncharacterized LOC137487716 Neighboring gene GRB2-associated binding protein 2 Neighboring gene uncharacterized LOC103908802 Neighboring gene uncharacterized LOC110437944

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC153218

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within asparaginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
asparaginyl-tRNA synthetase
Names
asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NP_001070623.1
XP_021337111.1
XP_068069669.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077155.1 → NP_001070623.1  asparaginyl-tRNA synthetase

    See identical proteins and their annotated locations for NP_001070623.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124277
    UniProtKB/TrEMBL
    Q08CE2
    Related
    ENSDARP00000130502.1, ENSDART00000171214.2
    Conserved Domains (3) summary
    PRK03932
    Location:34 → 482
    asnC; asparaginyl-tRNA synthetase; Validated
    cd00776
    Location:140 → 481
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04318
    Location:50 → 127
    EcAsnRS_like_N; EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    9601641..9631592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213568.1 → XP_068069669.1  asparaginyl-tRNA synthetase isoform X2

  2. XM_021481436.2 → XP_021337111.1  asparaginyl-tRNA synthetase isoform X1

    UniProtKB/TrEMBL
    A0A8M9QLG1
    Conserved Domains (1) summary
    PRK03932
    Location:34 → 502
    asnC; asparaginyl-tRNA synthetase; Validated
Nucleotide Protein Strain
Heading Accession and Version

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