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STK31 serine/threonine kinase 31 [ Homo sapiens (human) ]

Gene ID: 56164, updated on 14-Nov-2024

Summary

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Official Symbol
STK31provided by HGNC
Official Full Name
serine/threonine kinase 31provided by HGNC
Primary source
HGNC:HGNC:11407
See related
Ensembl:ENSG00000196335 MIM:605790; AllianceGenome:HGNC:11407
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDRD8; SGK396
Summary
This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 35.6) See more
Orthologs
mouse all
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Genomic context

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See STK31 in Genome Data Viewer
Location:
7p15.3
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (23710082..23832513)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (23849359..23971746)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (23749838..23872132)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 126 Neighboring gene FCF1 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23694754-23695254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25739 Neighboring gene family with sequence similarity 221 member A Neighboring gene NANOG hESC enhancer GRCh37_chr7:23763155-23763682 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:23763683-23764210 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 pseudogene 3 Neighboring gene MPRA-validated peak6439 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23867512-23868012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23884086-23884586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:23884587-23885087 Neighboring gene TPT1 pseudogene 7 Neighboring gene small nucleolar RNA U13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:23958471-23959023 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18016 Neighboring gene uncharacterized LOC105375188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. Kuo PL, et al. PLoS One, 2014. PMID 24667656, Free PMC Article
  2. STK31 maintains the undifferentiated state of colon cancer cells. Fok KL, et al. Carcinogenesis, 2012 Nov. PMID 22828137
  3. STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model. Bae DH, et al. Oncol Rep, 2021 Apr. PMID 33649810, Free PMC Article
  4. STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer. Zhong L, et al. Oncotarget, 2017 Apr 11. PMID 28412729, Free PMC Article
  5. The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer. Zhang K, et al. Oncotarget, 2017 May 23. PMID 28422722, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer.
    Title: Spastic Paraplegia 20 and Serine/Threonine Protein Kinase 31 Expression for the Detection of Colorectal Cancer.
  2. STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model.
    Title: STK31 upregulation is associated with chromatin remodeling in gastric cancer and induction of tumorigenicity in a xenograft mouse model.
  3. Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival.
    Title: Higher miR-543 levels correlate with lower STK31 expression and longer pancreatic cancer survival.
  4. STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/betacatenin pathway and feedback regulation by cmyc.
    Title: STK31 regulates the proliferation and cell cycle of lung cancer cells via the Wnt/β‑catenin pathway and feedback regulation by c‑myc.
  5. FBLN1 and STK31 can be possible screening and differentiating biomarkers of colorectal cancer
    Title: Serum FBLN1 and STK31 as biomarkers of colorectal cancer and their ability to noninvasively differentiate colorectal cancer from benign polyps.
  6. Relative STK31 expression level was significantly higher in patients with lymph node metastasis. STK31 expression levels in primary tumorous tissues of metastatic patients were significantly higher than in ANCTs and in lymph nodes samples, both at the RNA level and the protein level.
    Title: STK31 as novel biomarker of metastatic potential and tumorigenicity of colorectal cancer.
  7. Study demonstrates that, except the testes, STK31 is not expressed in normal tissues but aberrantly expressed in pancreatic cancer (PC) tissues, indicating that STK31 is a cancer-testis (CT) gene in PC. STK31 is reactivated by demethylation and, significantly higher in relapsed patients, or patients with advanced pathologic stage or poorer prognosis, suggesting that STK31 might be of potential clinical value.
    Title: The clinical value, regulatory mechanisms, and gene network of the cancer-testis gene STK31 in pancreatic cancer.
  8. The human papillomavirus type 16 oncogene E7 may affect STK31 expression through a DNA methylation-mediated mechanism.
    Title: Serine/threonine kinases 31(STK31) may be a novel cellular target gene for the HPV16 oncogene E7 with potential as a DNA hypomethylation biomarker in cervical cancer.
  9. the aberrant expression of STK31 contributes to tumorigenicity in somatic cancer cells
    Title: STK31 is a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells.
  10. High STK31 expression is associated with colon cancer.
    Title: STK31 maintains the undifferentiated state of colon cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16102

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 31
Names
serine/threonine-protein kinase NYD-SPK
sugen kinase 396
testis tissue sperm-binding protein Li 78m
tudor domain containing 8
NP_001247433.1
NP_001247434.1
NP_113602.2
NP_116562.2
XP_006715821.1
XP_011513751.2
XP_011513752.1
XP_011513754.2
XP_054214627.1
XP_054214628.1
XP_054214629.1
XP_054214630.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001260504.2 → NP_001247433.1  serine/threonine-protein kinase 31 isoform b

    See identical proteins and their annotated locations for NP_001247433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region, and initiates translation at a downstream AUG compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1. Variants 2 and 4 encode the same protein.
    Source sequence(s)
    AA315045, AC003087, AC008176, AF332194, AK131214, DA533364
    Consensus CDS
    CCDS43556.1
    UniProtKB/TrEMBL
    A0A140VKG1, A4D160
    Related
    ENSP00000346660.3, ENST00000354639.7
    Conserved Domains (2) summary
    cd20430
    Location:38 → 112
    Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
    cl21453
    Location:805 → 945
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001260505.2 → NP_001247434.1  serine/threonine-protein kinase 31 isoform c

    See identical proteins and their annotated locations for NP_001247434.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC003087, AC008176, AK302689
    Consensus CDS
    CCDS59049.1
    UniProtKB/TrEMBL
    A4D159
    Related
    ENSP00000411852.2, ENST00000433467.6
    Conserved Domains (3) summary
    cd04508
    Location:89 → 129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29 → 147
    TUDOR; Tudor domain
    cl21453
    Location:802 → 986
    PKc_like; Protein Kinases, catalytic domain

  3. NM_031414.5 → NP_113602.2  serine/threonine-protein kinase 31 isoform a

    See identical proteins and their annotated locations for NP_113602.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC003087, BC059374, DB065148
    Consensus CDS
    CCDS5386.1
    UniProtKB/Swiss-Prot
    B4DZ06, B7WPP5, C9J4F9, Q6PCD3, Q9BXH8, Q9BXU1
    UniProtKB/TrEMBL
    A4D159
    Related
    ENSP00000348132.3, ENST00000355870.8
    Conserved Domains (3) summary
    cd04508
    Location:89 → 129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29 → 147
    TUDOR; Tudor domain
    cl21453
    Location:802 → 921
    PKc_like; Protein Kinases, catalytic domain

  4. NM_032944.4 → NP_116562.2  serine/threonine-protein kinase 31 isoform b

    See identical proteins and their annotated locations for NP_116562.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice-site in the 5' end that results in translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform b) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC003087, AC008176, BC059374, DB095141
    Consensus CDS
    CCDS43556.1
    UniProtKB/TrEMBL
    A0A140VKG1, A4D160
    Conserved Domains (2) summary
    cd20430
    Location:38 → 112
    Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
    cl21453
    Location:805 → 945
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_048542.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in a 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA315045, AC003087, AC008176, AK131214, BC033018, DB089624

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    23710082..23832513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515452.4 → XP_011513754.2  serine/threonine-protein kinase 31 isoform X3

    UniProtKB/TrEMBL
    A4D160

  2. XM_011515449.4 → XP_011513751.2  serine/threonine-protein kinase 31 isoform X1

    UniProtKB/TrEMBL
    A4D160
    Related
    ENSP00000519677.1, ENST00000528479.6

  3. XM_006715758.5 → XP_006715821.1  serine/threonine-protein kinase 31 isoform X4

    UniProtKB/TrEMBL
    A4D159
    Conserved Domains (3) summary
    cd04508
    Location:89 → 129
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:29 → 147
    TUDOR; Tudor domain
    cl21453
    Location:624 → 743
    PKc_like; Protein Kinases, catalytic domain

  4. XM_011515450.2 → XP_011513752.1  serine/threonine-protein kinase 31 isoform X2

    See identical proteins and their annotated locations for XP_011513752.1

    UniProtKB/TrEMBL
    A0A140VKG1, A4D160
    Conserved Domains (2) summary
    cd20430
    Location:38 → 112
    Tudor_TDRD8; Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins
    cl21453
    Location:805 → 945
    PKc_like; Protein Kinases, catalytic domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    23849359..23971746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358654.1 → XP_054214629.1  serine/threonine-protein kinase 31 isoform X3

  2. XM_054358652.1 → XP_054214627.1  serine/threonine-protein kinase 31 isoform X1

  3. XM_054358655.1 → XP_054214630.1  serine/threonine-protein kinase 31 isoform X4

  4. XM_054358653.1 → XP_054214628.1  serine/threonine-protein kinase 31 isoform X2

    UniProtKB/TrEMBL
    A0A140VKG1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001122833.1: Suppressed sequence

    Description
    NM_001122833.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BXU1.2 GenPept UniProtKB/Swiss-Prot:Q9BXU1

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