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ntn4 netrin 4 [ Danio rerio (zebrafish) ]

Gene ID: 561440, updated on 12-Sep-2024

Summary

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Official Symbol
ntn4provided by ZNC
Official Full Name
netrin 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-050310-1
See related
Ensembl:ENSDARG00000102066 AllianceGenome:ZFIN:ZDB-GENE-050310-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Acts upstream of or within blood vessel morphogenesis. Predicted to be located in extracellular region. Predicted to be part of laminin complex. Is expressed in blood vessel; brain; neural rod; tail bud; and trunk. Orthologous to human NTN4 (netrin 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ntn4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (19334515..19369078, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (19082059..19117827, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene interleukin 13 receptor, alpha 1 Neighboring gene dedicator of cytokinesis 11 Neighboring gene uncharacterized LOC110439931 Neighboring gene small nuclear ribonucleoprotein polypeptide F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Netrin-4 acts as a pro-angiogenic factor during zebrafish development. Lambert E, et al. J Biol Chem, 2012 Feb 3. PMID 22179604, Free PMC Article
  2. Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4. Park KW, et al. Dev Dyn, 2005 Nov. PMID 15973704, Free PMC Article
  3. A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. Gao X, et al. Cell Rep, 2015 Jul 28. PMID 26190107
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the crucial role of Netrin-4 in blood vessel formation and the involvement of protein kinases activation in Netrin-4-induced biological effects related to vascular development.
    Title: Netrin-4 acts as a pro-angiogenic factor during zebrafish development.
  2. netrin 4 is detected only at very low levels during early development
    Title: Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in basement membrane assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
part_of laminin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
netrin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430983.1 → NP_001417912.1  netrin-4 precursor

    Status: VALIDATED

    Source sequence(s)
    CABZ01018576, CABZ01018577, CABZ01018578, CU571321
    UniProtKB/TrEMBL
    Q32SK8
    Related
    ENSDARP00000132076.1, ENSDART00000165680.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    19334515..19369078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394683.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    71484..101035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037686.1: Suppressed sequence

    Description
    NM_001037686.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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