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cacna2d1a calcium channel, voltage-dependent, alpha 2/delta subunit 1a [ Danio rerio (zebrafish) ]

Gene ID: 561434, updated on 2-Nov-2024

Summary

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Official Symbol
cacna2d1aprovided by ZNC
Official Full Name
calcium channel, voltage-dependent, alpha 2/delta subunit 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-215
See related
Ensembl:ENSDARG00000014804 AllianceGenome:ZFIN:ZDB-GENE-041210-215
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-251k4.1
Summary
Predicted to enable voltage-gated calcium channel activity. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of L-type voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See cacna2d1a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (19764093..19884128, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (19775850..19895190, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene paired box 4 Neighboring gene hepatocyte growth factor a Neighboring gene cadherin-related family member 5, related sequence Neighboring gene uncharacterized LOC110439363 Neighboring gene dopamine receptor D4 related sequence

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Horstick EJ, et al. Nat Commun, 2013. PMID 23736855, Free PMC Article
  2. asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. Cai W, et al. Int J Mol Sci, 2023 Nov 15. PMID 38003559, Free PMC Article
  3. Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Cardoso JC, et al. J Mol Endocrinol, 2016 Jul. PMID 27220618
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel subunit alpha-2/delta-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044960.2 → NP_001038425.2  voltage-dependent calcium channel subunit alpha-2/delta-1a precursor

    Status: PROVISIONAL

    Source sequence(s)
    BX323820
    UniProtKB/TrEMBL
    A0A8N1YYV6, Q5TZ68
    Related
    ENSDARP00000027410.6, ENSDART00000014440.7
    Conserved Domains (4) summary
    pfam02743
    Location:444 → 530
    Cache_1; Cache domain
    pfam08399
    Location:110 → 224
    VWA_N; VWA N-terminal
    pfam08473
    Location:543 → 627
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl00057
    Location:237 → 415
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    19764093..19884128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164746.5 → XP_005164803.1  voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X4

    UniProtKB/TrEMBL
    A0A8M2BBW2
    Conserved Domains (4) summary
    pfam02743
    Location:444 → 532
    Cache_1; Cache domain
    pfam08399
    Location:110 → 224
    VWA_N; VWA N-terminal
    pfam08473
    Location:545 → 629
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl00057
    Location:237 → 415
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. XM_009300288.4 → XP_009298563.1  voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X3

    UniProtKB/TrEMBL
    A0A8M3AYS1
    Conserved Domains (4) summary
    pfam02743
    Location:444 → 532
    Cache_1; Cache domain
    pfam08399
    Location:110 → 224
    VWA_N; VWA N-terminal
    pfam08473
    Location:545 → 629
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl00057
    Location:237 → 415
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_068219662.1 → XP_068075763.1  voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X2

  4. XM_009300286.4 → XP_009298561.1  voltage-dependent calcium channel subunit alpha-2/delta-1a isoform X1

    UniProtKB/TrEMBL
    A0A8M3ARM5
    Conserved Domains (4) summary
    pfam02743
    Location:444 → 532
    Cache_1; Cache domain
    pfam08399
    Location:110 → 224
    VWA_N; VWA N-terminal
    pfam08473
    Location:545 → 627
    VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
    cl00057
    Location:237 → 415
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version

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