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myh9b myosin, heavy chain 9b, non-muscle [ Danio rerio (zebrafish) ]

Gene ID: 561431, updated on 2-Nov-2024

Summary

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Official Symbol
myh9bprovided by ZNC
Official Full Name
myosin, heavy chain 9b, non-muscleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-998
See related
Ensembl:ENSDARG00000001014 AllianceGenome:ZFIN:ZDB-GENE-030131-998
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
myh9l1; fb55d12; wu:fb30g06; wu:fb55d12; si:ch211-150d5.2
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within several processes, including actin filament bundle distribution; cardiac ventricle development; and midbrain-hindbrain boundary morphogenesis. Predicted to be located in cortical granule. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in several structures, including brain; ectoderm; epidermis; eye; and pectoral fin. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See myh9b in Genome Data Viewer
Location:
chromosome: 3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (5127744..5228135, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (5217903..5318521, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene TEF transcription factor, PAR bZIP family member b Neighboring gene myb-like protein D Neighboring gene uncharacterized LOC101886256 Neighboring gene thioredoxin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Huang Y, et al. Gene Expr Patterns, 2013 Oct. PMID 23665442
  2. Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis. Gutzman JH, et al. Dev Biol, 2015 Jan 1. PMID 25446029
  3. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. Lou SS, et al. J Cell Biol, 2015 Apr 27. PMID 25918227, Free PMC Article
  4. Application of an F0-based genetic assay in adult zebrafish to identify modifier genes of an inherited cardiomyopathy. Ding Y, et al. Dis Model Mech, 2023 May 1. PMID 35481478, Free PMC Article
  5. Expression of unconventional myosin genes during neuronal development in zebrafish. Sittaramane V, et al. Gene Expr Patterns, 2008 Feb. PMID 18078791, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament bundle distribution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cardiac ventricle development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical granule IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
myosin-9
Names
myh91
myhz9
myo2hc9
myosin, heavy chain 9, non-muscle like-1
myosin, heavy polypeptide 9b, non-muscle

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    5127744..5228135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163701.5 → XP_005163758.1  myosin-9 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BB06
    Related
    ENSDARP00000114437.2, ENSDART00000137105.3
    Conserved Domains (11) summary
    cl22853
    Location:93 → 760
    Motor_domain; Myosin and Kinesin motor domain
    pfam00038
    Location:1027 → 1334
    Filament; Intermediate filament protein
    pfam00063
    Location:81 → 760
    Myosin_head; Myosin head (motor domain)
    pfam02736
    Location:28 → 66
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam09311
    Location:1299 → 1599
    Rab5-bind; Rabaptin-like protein
    pfam14662
    Location:930 → 1113
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cd16269
    Location:1653 → 1662
    GBP_C; coiled coil [structural motif]
    cl03075
    Location:1525 → 1633
    GrpE; nucleotide exchange factor GrpE
    cl15415
    Location:936 → 1069
    Sec1; Sec1 family
    cl19297
    Location:1011 → 1168
    Dor1; Dor1-like family
    cl20817
    Location:1589 → 1682
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_001920063.8 → XP_001920098.4  myosin-9 isoform X1

    See identical proteins and their annotated locations for XP_001920098.4

    UniProtKB/TrEMBL
    A0A8M1QUS6
    Related
    ENSDARP00000086805.7, ENSDART00000092373.7
    Conserved Domains (11) summary
    cl22853
    Location:93 → 767
    Motor_domain; Myosin and Kinesin motor domain
    pfam00038
    Location:1034 → 1341
    Filament; Intermediate filament protein
    pfam00063
    Location:81 → 767
    Myosin_head; Myosin head (motor domain)
    pfam02736
    Location:28 → 66
    Myosin_N; Myosin N-terminal SH3-like domain
    pfam09311
    Location:1306 → 1606
    Rab5-bind; Rabaptin-like protein
    pfam14662
    Location:937 → 1120
    KASH_CCD; Coiled-coil region of CCDC155 or KASH
    cd16269
    Location:1660 → 1669
    GBP_C; coiled coil [structural motif]
    cl03075
    Location:1532 → 1640
    GrpE; nucleotide exchange factor GrpE
    cl15415
    Location:943 → 1076
    Sec1; Sec1 family
    cl19297
    Location:1018 → 1175
    Dor1; Dor1-like family
    cl20817
    Location:1596 → 1689
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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