hcrtr2 hypocretin (orexin) receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hcrtr2provided by ZNC
Official Full Name: hypocretin (orexin) receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-070228-3
See related: Ensembl:ENSDARG00000023722 AllianceGenome:ZFIN:ZDB-GENE-070228-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hcrtr
Summary: Predicted to enable orexin receptor activity. Acts upstream of or within circadian behavior; melatonin metabolic process; and regulation of circadian sleep/wake cycle, sleep. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain and spinal cord. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (2020215..2060671, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (1888924..1929380, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that fish lacking the hypocretin receptor demonstrate short and fragmented sleep in the dark, in striking contrast to the excessive sleepiness and cataplexy of narcolepsy in mammals.
Title: Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables orexin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables orexin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within circadian behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian sleep/wake cycle process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within feeding behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within melatonin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: orexin receptor type 2

Names: hcrt receptor; hypocretin orexin receptor; hypocretin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079868.1 → NP_001073337.1 orexin receptor type 2

See identical proteins and their annotated locations for NP_001073337.1

Status: PROVISIONAL

Source sequence(s)

EF122429

UniProtKB/TrEMBL

A0A8M1NC97, A1YQE3

Related

ENSDARP00000029101.7, ENSDART00000038434.8

Conserved Domains (3) summary

pfam00001
Location:71 → 364

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam03827
Location:390 → 424

Orexin_rec2; Orexin receptor type 2

cl21561
Location:65 → 185

7tm_4; Olfactory receptor