Gorasp1 golgi reassembly stacking protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gorasp1provided by RGD
Official Full Name: golgi reassembly stacking protein 1provided by RGD
Primary source: RGD:621122
See related: EnsemblRapid:ENSRNOG00000018047 AllianceGenome:RGD:621122
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GRASP65
Summary: Predicted to enable metal ion binding activity. Involved in Golgi organization and negative regulation of dendrite morphogenesis. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human GORASP1 (golgi reassembly stacking protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 99.5), Kidney (RPKM 88.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (128532933..128544686, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (119655267..119667022, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (128610290..128622337, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRASP65 and GRASP55 proteins have roles in Golgi membrane stacking
Title: Structural insight into Golgi membrane stacking by GRASP65 and GRASP55 proteins.
Dendrites in Grasp65 knockdown granule neurons are longer and more highly branched than dendrites in control neurons.
Title: An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.
Golgi remodeling, mediated by phosphorylation of GRASP65 by ERK, is critical for the establishment of cell polarity in migrating cells.
Title: ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65.
GRASP65 may function as a signal integrator controlling the cell growth
Title: Convergence of cell cycle regulation and growth factor signals on GRASP65.
Cdk1-cyclin B is the major kinase phosphorylating GRASP65 in mitosis
Title: Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127721 (e-PCR)
- UniSTS:211031

MARC_16103-16104:1018028206:1 (e-PCR)
- UniSTS:267961

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IDA Inferred from Direct Assay more info	PubMed
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	IEA Inferred from Electronic Annotation more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein N-linked glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein N-linked glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: Golgi reassembly-stacking protein 1

Names: golgi peripheral membrane protein p65; golgi reassembly-stacking protein of 65 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019385.2 → NP_062258.2 Golgi reassembly-stacking protein 1

See identical proteins and their annotated locations for NP_062258.2

Status: VALIDATED

Source sequence(s)

BC161850

UniProtKB/Swiss-Prot

O35254

UniProtKB/TrEMBL

B1WBR1, F7ERK9

Related

ENSRNOP00000024408.2, ENSRNOT00000024408.6

Conserved Domains (2) summary

pfam04495
Location:68 → 204

GRASP55_65; GRASP55/65 PDZ-like domain

cl00117
Location:14 → 99

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...