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Dgke diacylglycerol kinase, epsilon [ Mus musculus (house mouse) ]

Gene ID: 56077, updated on 2-Nov-2024

Summary

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Official Symbol
Dgkeprovided by MGI
Official Full Name
diacylglycerol kinase, epsilonprovided by MGI
Primary source
MGI:MGI:1889276
See related
Ensembl:ENSMUSG00000000276 AllianceGenome:MGI:1889276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DGK; DAGK6; DGK-epsilon
Summary
Predicted to enable ATP-dependent diacylglycerol kinase activity. Involved in modulation of chemical synaptic transmission and phosphatidylinositol biosynthetic process. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 19.4), cerebellum adult (RPKM 8.7) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Dgke in Genome Data Viewer
Location:
11 C; 11 54.34 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (88926005..88951644, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (89035179..89060795, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene coilin Neighboring gene STARR-seq mESC enhancer starr_30379 Neighboring gene STARR-seq mESC enhancer starr_30380 Neighboring gene STARR-positive B cell enhancer ABC_E9837 Neighboring gene predicted gene 11496 Neighboring gene tripartite motif-containing 25 Neighboring gene STARR-positive B cell enhancer ABC_E2363 Neighboring gene STARR-positive B cell enhancer ABC_E5263 Neighboring gene STARR-positive B cell enhancer ABC_E5264 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88919911-88920094 Neighboring gene STARR-positive B cell enhancer ABC_E1840 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88927428-88927537 Neighboring gene STARR-seq mESC enhancer starr_30387 Neighboring gene diacylglycerol kinase, epsilon, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E7043 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88938900-88939236 Neighboring gene STARR-positive B cell enhancer ABC_E8442 Neighboring gene predicted gene 525 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:88956596-88956973 Neighboring gene predicted gene, 22534 Neighboring gene STARR-seq mESC enhancer starr_30389 Neighboring gene predicted gene, 38759

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular species of phosphatidylinositol-cycle intermediates in the endoplasmic reticulum and plasma membrane. Shulga YV, et al. Biochemistry, 2010 Jan 19. PMID 20000336, Free PMC Article
  2. Ablation of diacylglycerol kinase ε promotes whitening of brown adipose tissue under high fat diet feeding. Nakano T, et al. Adv Biol Regul, 2024 Jan. PMID 37875386
  3. Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production. Zhu J, et al. Am J Physiol Renal Physiol, 2016 May 1. PMID 26887830, Free PMC Article
  4. Diacylglycerol kinase epsilon protects against renal ischemia/reperfusion injury in mice through Krüppel-like factor 15/klotho pathway. Wang Z, et al. Ren Fail, 2022 Dec. PMID 35616094, Free PMC Article
  5. Epileptogenesis in diacylglycerol kinase epsilon deficiency up-regulates COX-2 and tyrosine hydroxylase in hippocampus. Lukiw WJ, et al. Biochem Biophys Res Commun, 2005 Dec 9. PMID 16137646

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ablation of diacylglycerol kinase epsilon promotes whitening of brown adipose tissue under high fat diet feeding.
    Title: Ablation of diacylglycerol kinase ε promotes whitening of brown adipose tissue under high fat diet feeding.
  2. Diacylglycerol kinase-epsilon is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment.
    Title: Diacylglycerol kinase-ε is S-palmitoylated on cysteine in the cytoplasmic end of its N-terminal transmembrane fragment.
  3. An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-epsilon.
    Title: An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-ε.
  4. Diacylglycerol kinase epsilon protects against renal ischemia/reperfusion injury in mice through Kruppel-like factor 15/klotho pathway.
    Title: Diacylglycerol kinase epsilon protects against renal ischemia/reperfusion injury in mice through Krüppel-like factor 15/klotho pathway.
  5. Loss of diacylglycerol kinase epsilon causes thrombotic microangiopathy by impairing endothelial VEGFA signaling.
    Title: Loss of diacylglycerol kinase ε causes thrombotic microangiopathy by impairing endothelial VEGFA signaling.
  6. Diacylglycerol kinase zeta promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse.
    Title: Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse.
  7. Mice lacking DGKepsilon show increased beige adipogenesis in visceral white adipose tissue after long-term high fat diet in a COX-2- dependent manner.
    Title: Mice lacking DGKε show increased beige adipogenesis in visceral white adipose tissue after long-term high fat diet in a COX-2- dependent manner.
  8. DGKepsilon plays a role in glucose and energy homeostasis by modulating lipid metabolism in skeletal muscle
    Title: Diacylglycerol kinase ε deficiency preserves glucose tolerance and modulates lipid metabolism in obese mice.
  9. Our results unveil an unexpected role of Dgke in the induction of cyclooxygenase-2 and in the regulation of glomerular prostanoids synthesis under stress
    Title: Loss of diacylglycerol kinase epsilon in mice causes endothelial distress and impairs glomerular Cox-2 and PGE2 production.
  10. Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.
    Title: Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent diacylglycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in diacylglycerol metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
diacylglycerol kinase epsilon
Names
DAG kinase epsilon
diglyceride kinase epsilon
NP_001349774.1
NP_062378.1
XP_011247453.1
XP_036012756.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362845.1 → NP_001349774.1  diacylglycerol kinase epsilon isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL646096
    Conserved Domains (4) summary
    smart00046
    Location:218 → 346
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:122 → 166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00130
    Location:58 → 107
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02440
    Location:366 → 505
    DAGK_acc; Diacylglycerol kinase accessory domain

  2. NM_019505.4 → NP_062378.1  diacylglycerol kinase epsilon isoform 1

    See identical proteins and their annotated locations for NP_062378.1

    Status: VALIDATED

    Source sequence(s)
    AK049335, AK147841, AL646096, BB635763
    Consensus CDS
    CCDS25234.1
    UniProtKB/Swiss-Prot
    Q5SU69, Q9R1C6
    Related
    ENSMUSP00000000285.3, ENSMUST00000000285.9
    Conserved Domains (5) summary
    TIGR00147
    Location:216 → 526
    TIGR00147; lipid kinase, YegS/Rv2252/BmrU family
    smart00045
    Location:366 → 521
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:218 → 346
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:122 → 166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00130
    Location:58 → 107
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RNA

  1. NR_156181.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK147841, AL646096

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    88926005..88951644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249151.4 → XP_011247453.1  diacylglycerol kinase epsilon isoform X2

    UniProtKB/TrEMBL
    Q8C8R9
    Conserved Domains (4) summary
    smart00046
    Location:218 → 346
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd00029
    Location:122 → 166
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    pfam00130
    Location:58 → 105
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    cl02440
    Location:366 → 505
    DAGK_acc; Diacylglycerol kinase accessory domain

  2. XM_036156863.1 → XP_036012756.1  diacylglycerol kinase epsilon isoform X1

    Conserved Domains (4) summary
    smart00045
    Location:326 → 481
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:206 → 306
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd20801
    Location:55 → 108
    C1_DGKepsilon_typeIII_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins
    cd20853
    Location:122 → 186
    C1_DGKepsilon_typeIII_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type III diacylglycerol kinase, DAG kinase epsilon, and similar proteins

RNA

  1. XR_001780032.3 RNA Sequence

  2. XR_004936996.1 RNA Sequence

  3. XR_004936995.1 RNA Sequence

  4. XR_004936997.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1C6.1 GenPept UniProtKB/Swiss-Prot:Q9R1C6

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