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otpa orthopedia homeobox a [ Danio rerio (zebrafish) ]

Gene ID: 560759, updated on 12-Sep-2024

Summary

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Official Symbol
otpaprovided by ZNC
Official Full Name
orthopedia homeobox aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070216-1
See related
Ensembl:ENSDARG00000014201 AllianceGenome:ZFIN:ZDB-GENE-070216-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable DNA binding activity. Involved in myelination. Acts upstream of or within nervous system development; social behavior; and visual behavior. Predicted to be located in nucleus. Is expressed in hematopoietic stem cell and nervous system. Orthologous to human OTP (orthopedia homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See otpa in Genome Data Viewer
Location:
chromosome: 21
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (7581958..7586546)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (7842378..7848882)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488780 Neighboring gene tubulin cofactor a Neighboring gene WD repeat domain 41 Neighboring gene phosphodiesterase 8B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A versatile transcription factor: Multiple roles of orthopedia a (otpa) beyond its restricted localization in dopaminergic systems of developing and adult zebrafish (Danio rerio) brains. Eugenin von Bernhardi J, et al. J Comp Neurol, 2022 Oct. PMID 35708548
  2. Identification of accessory olfactory system and medial amygdala in the zebrafish. Biechl D, et al. Sci Rep, 2017 Mar 14. PMID 28290515, Free PMC Article
  3. Classification of object size in retinotectal microcircuits. Preuss SJ, et al. Curr Biol, 2014 Oct 20. PMID 25242030
  4. Single-Cell Reconstruction of Oxytocinergic Neurons Reveals Separate Hypophysiotropic and Encephalotropic Subtypes in Larval Zebrafish. Herget U, et al. eNeuro, 2017 Jan-Feb. PMID 28317020, Free PMC Article
  5. Integrative systems and functional analyses reveal a role of dopaminergic signaling in myelin pathogenesis. Ding S, et al. J Transl Med, 2020 Mar 2. PMID 32122379, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings reveal a new role for Otp in controlling developmental neuropeptide balance in a discrete oxytocinergic hypothalamic circuit whose disrupted development affects social behavior.
    Title: Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior.
  2. These observations suggest that the requirement for otpa and otpb function during development of the larval diencephalon is partially redundant.
    Title: Orthopedia transcription factor otpa and otpb paralogous genes function during dopaminergic and neuroendocrine cell specification in larval zebrafish.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain neuron development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within forebrain neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mammillary body development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myelination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
orthopedia homeobox a
Names
orthopedia homolog a
otp
otp2
otpb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128703.1 → NP_001122175.1  orthopedia homeobox a

    See identical proteins and their annotated locations for NP_001122175.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162329
    UniProtKB/TrEMBL
    A0A8N7XJD8, B3DGA5, B3DGA7, E9QGH0
    Related
    ENSDARP00000122571.2, ENSDART00000135485.3
    Conserved Domains (2) summary
    pfam00046
    Location:117 → 165
    Homeobox; Homeobox domain
    pfam03826
    Location:309 → 326
    OAR; OAR domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    7581958..7586546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170249.5 → XP_005170306.1  orthopedia homeobox a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BHN1, F6NUE7
    Related
    ENSDARP00000015517.7, ENSDART00000027268.8
    Conserved Domains (2) summary
    pfam00046
    Location:104 → 152
    Homeobox; Homeobox domain
    pfam03826
    Location:296 → 313
    OAR; OAR domain
Nucleotide Protein
Heading Accession and Version

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