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mettl4 methyltransferase 4, N6-adenosine [ Danio rerio (zebrafish) ]

Gene ID: 560686, updated on 18-Sep-2024

Summary

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Official Symbol
mettl4provided by ZNC
Official Full Name
methyltransferase 4, N6-adenosineprovided by ZNC
Primary source
ZFIN:ZDB-GENE-130129-2
See related
Ensembl:ENSDARG00000088999 AllianceGenome:ZFIN:ZDB-GENE-130129-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable methyltransferase activity and nucleic acid binding activity. Predicted to act upstream of or within methylation. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mettl4 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (71576155..71584926, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (71336464..71343820, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene thymidylate synthetase Neighboring gene adenylate cyclase activating polypeptide 1a Neighboring gene structural maintenance of chromosomes flexible hinge domain containing 1 Neighboring gene structural maintenance of chromosomes flexible hinge domain-containing protein 1-like Neighboring gene elastin microfibril interfacer 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a nucleic acid IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N(6)-adenine-specific methyltransferase METTL4
Names
methyltransferase like 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    71576155..71584926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478062.2 → XP_021333737.1  N(6)-adenine-specific methyltransferase METTL4 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PQD5
    Conserved Domains (1) summary
    cl01947
    Location:213 → 385
    MT-A70

  2. XM_684086.9 → XP_689178.3  N(6)-adenine-specific methyltransferase METTL4 isoform X1

    UniProtKB/TrEMBL
    A0A8N7T6Z4, E7F6U3
    Related
    ENSDARP00000108647.1, ENSDART00000128678.3
    Conserved Domains (1) summary
    cl01947
    Location:235 → 407
    MT-A70; MT-A70

  3. XM_068222794.1 → XP_068078895.1  N(6)-adenine-specific methyltransferase METTL4 isoform X3

Nucleotide Protein
Heading Accession and Version

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