Rala v-ral simian leukemia viral oncogene A (ras related) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ralaprovided by MGI
Official Full Name: v-ral simian leukemia viral oncogene A (ras related)provided by MGI
Primary source: MGI:MGI:1927243
See related: Ensembl:ENSMUSG00000008859 AllianceGenome:MGI:1927243
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ral; Rasl1; 3010001O15Rik
Summary: Enables GTPase activity. Involved in membrane raft localization; neural tube closure; and regulation of exocytosis. Located in myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; eye; heart; and skin. Orthologous to human RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 28.4), CNS E14 (RPKM 21.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A2; 13 6.05 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (18055160..18118802, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (17880575..17944217, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Title: Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse.
Title: Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse.
RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
Title: RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
While lack of only one Ral GTPase was dispensable for early peripheral nerve development, ablation of both RalA and RalB resulted in persistent radial sorting defects, associated with hallmarks of deficits in Schwann cell process formation and maintenance.
Title: Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system.
Ablation of both RalA and RalB (but not individually) in Schwann cell resulted in impaired axon remyelination and target reinnervation following nerve injury, which resulted in slowed recovery of motor function.
Title: RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation.
Platelet Ral GTPases primarily control P-selectin surface expression, in turn regulating platelet-leukocyte interaction.
Title: Mouse Platelet Ral GTPases Control P-Selectin Surface Expression, Regulating Platelet-Leukocyte Interaction.
RalA plays a crucial role in glucose transport in adipose tissue in vivo.
Title: RalA controls glucose homeostasis by regulating glucose uptake in brown fat.
This study identifies a novel regulatory crosstalk between Ral and Arf6 that controls Ral function in cells.
Title: Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.
striking isoform-specific consequences of distinct CAAX-signaled posttranslational modifications that contribute to the divergent subcellular localization and activity of RalA and RalB.
Title: Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases.
RalA activation was remarkably impaired in rac1-deficient skeletal muscle fibres.
Title: Role for RalA downstream of Rac1 in skeletal muscle insulin signalling.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW322615 (e-PCR)
- UniSTS:185965

D13Mit56 (e-PCR), detects polymorphism
- UniSTS:127154

NoName (e-PCR)
- UniSTS:236981

Rasl1 (e-PCR), detects polymorphism
- UniSTS:144329

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables Edg-2 lysophosphatidic acid receptor binding	ISO Inferred from Sequence Orthology more info
enables Edg-2 lysophosphatidic acid receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	EXP Inferred from Experiment more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables myosin binding	IEA Inferred from Electronic Annotation more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in membrane raft localization	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane raft localization	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in endocytic vesicle	IEA Inferred from Electronic Annotation more info
colocalizes_with endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in myelin sheath	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Ral-A

Names: RAS-like, family 1; ral-A protein; v-ral simian leukemia viral oncogene homolog A (ras related)

NP_062364.3

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019491.5 → NP_062364.3 ras-related protein Ral-A

See identical proteins and their annotated locations for NP_062364.3

Status: PROVISIONAL

Source sequence(s)

CT009754

Consensus CDS

CCDS26255.1

UniProtKB/Swiss-Prot

P63321

UniProtKB/TrEMBL

Q9CXY0

Related

ENSMUSP00000009003.8, ENSMUST00000009003.9

Conserved Domains (1) summary

cd04139
Location:15 → 177

RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB