cul4b cullin 4B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cul4bprovided by ZNC
Official Full Name: cullin 4Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041008-208
See related: Ensembl:ENSDARG00000060510 AllianceGenome:ZFIN:ZDB-GENE-041008-208
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7140950; im:7150765
Summary: Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to DNA damage stimulus; and protein ubiquitination. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of Cul4B-RING E3 ubiquitin ligase complex. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Cabezas type. Orthologous to human CUL4B (cullin 4B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (33486151..33505709)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (33145837..33165395)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that cul4a but not cul4b is required for the expression of tbx5a, an essential transcription factor in heart and limb development.
Title: Zebrafish cul4a, but not cul4b, modulates cardiac and forelimb development by upregulating tbx5a expression.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4B-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cullin-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cullin-4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122844.1 → NP_001116316.1 cullin-4B

Status: PROVISIONAL

Source sequence(s)

BX004980

UniProtKB/TrEMBL

A0A8M1NIA7, F8W428

Related

ENSDARP00000124267.1, ENSDART00000149254.3

Conserved Domains (3) summary

smart00182
Location:547 → 687

CULLIN; Cullin

smart00884
Location:793 → 858

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:169 → 764

Cullin; Cullin family