cax1 cation/H+ exchanger protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cax1provided by ZNC
Official Full Name: cation/H+ exchanger protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3044
See related: Ensembl:ENSDARG00000045601 AllianceGenome:ZFIN:ZDB-GENE-030131-3044
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc25f10; zgc:136271; si:dkey-180p18.2
Summary: Predicted to enable calcium:proton antiporter activity. Acts upstream of or within calcium ion transport and neural crest cell development. Located in endomembrane system. Is expressed in neural crest cell. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (14981846..14990888)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (14983091..14992133)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

initiate characterization of a zebrafish CAX (Cax1); In zebrafish embryos, cax1 was specifically expressed in neural crest cells and was required for animal growth and development.
Title: Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi30a08.x1 (e-PCR)
- UniSTS:197226

fc25f10.x1 (e-PCR)
- UniSTS:193270

fc25f10.x1 (e-PCR)
- UniSTS:193271

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cation/H+ exchanger protein 1

Names: type II CAX cation/proton exchanger

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025507.3 → NP_001020678.2 cation/H+ exchanger protein 1

See identical proteins and their annotated locations for NP_001020678.2

Status: PROVISIONAL

Source sequence(s)

BC133106

UniProtKB/TrEMBL

A3KMS2, Q156I9, Q5RH62

Related

ENSDARP00000067045.4, ENSDART00000067046.5

Conserved Domains (3) summary

COG0387
Location:354 → 759

ChaA; Ca2+/H+ antiporter [Inorganic ion transport and metabolism]

pfam01699
Location:613 → 757

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03733
Location:156 → 205

YccF; Inner membrane component domain