il34 interleukin 34 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: il34provided by ZNC
Official Full Name: interleukin 34provided by ZNC
Primary source: ZFIN:ZDB-GENE-050419-150
See related: Ensembl:ENSDARG00000091003 AllianceGenome:ZFIN:ZDB-GENE-050419-150
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: IL-34; si:ch211-239j19.3
Summary: Predicted to enable cytokine activity and macrophage colony-stimulating factor receptor binding activity. Acts upstream of with a positive effect on macrophage migration. Acts upstream of or within microglia development. Predicted to be active in extracellular space. Orthologous to human IL34 (interleukin 34). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (18527173..18543358, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (18538107..18554292, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration.
Title: The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration.
il34 is a modifier of microglia colonization, by affecting distribution of yolk sac macrophage to target organs.
Title: Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables macrophage colony-stimulating factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables macrophage colony-stimulating factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microglia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of monocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: interleukin-34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.