vtg2 vitellogenin 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: vtg2provided by ZNC
Official Full Name: vitellogenin 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-001201-2
See related: Ensembl:ENSDARG00000055809 AllianceGenome:ZFIN:ZDB-GENE-001201-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: vg2; zfVtg2; si:dkey-4c23.2
Summary: Enables lipopolysaccharide binding activity and lipoteichoic acid binding activity. Acts upstream of or within positive regulation of phagocytosis, engulfment and response to estradiol. Is expressed in atrium; intestine; liver; and ovary. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 22

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (24869690..24880824, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (24842066..24853200, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio).
Title: Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio).
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta after a 21-day exposure to endocrine-disrupting chemicals.
Title: Temperature and photoperiod affect the endocrine disruption effects of ethinylestradiol, nonylphenol and their binary mixture in zebrafish (Danio rerio).

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables lipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid transporter activity	IEA Inferred from Electronic Annotation more info
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipoteichoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables nutrient reservoir activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to estradiol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: vitellogenin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044913.1 → NP_001038378.1 vitellogenin 2 precursor

Status: PROVISIONAL

Source sequence(s)

AL929032

UniProtKB/TrEMBL

A0A8M1N9S5, Q1MTC4

Related

ENSDARP00000061164.5, ENSDART00000061165.7

Conserved Domains (4) summary

smart00216
Location:1362 → 1519

VWD; von Willebrand factor (vWF) type D domain

pfam01347
Location:24 → 592

Vitellogenin_N; Lipoprotein amino terminal region

pfam09172
Location:626 → 917

DUF1943; Domain of unknown function (DUF1943)

pfam09175
Location:1167 → 1331

DUF1944; Domain of unknown function (DUF1944)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007133.7 Reference GRCz11 Primary Assembly

Range

24869690..24880824 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018395108.1 Reference GRCz11 ALT_DRER_TU_1

Range

220317..231426 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

NW_018395353.1 Reference GRCz11 ALT_DRER_TU_2

Range

34158..45292 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001110384.1: Suppressed sequence

Description

NM_001110384.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.