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acsl3b acyl-CoA synthetase long chain family member 3b [ Danio rerio (zebrafish) ]

Gene ID: 559656, updated on 2-Nov-2024

Summary

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Official Symbol
acsl3bprovided by ZNC
Official Full Name
acyl-CoA synthetase long chain family member 3bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-492
See related
Ensembl:ENSDARG00000014674 AllianceGenome:ZFIN:ZDB-GENE-030131-492
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
acsl3; fa07a08; im:7155129; wu:fa07a08; wu:fb34c03; si:dkey-20f20.5
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See acsl3b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (47471952..47515390)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (47619385..47662886)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene paired box 3a Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC108180073 Neighboring gene secretogranin II b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates. Lopes-Marques M, et al. BMC Evol Biol, 2013 Dec 12. PMID 24330521, Free PMC Article
  2. Sequential actions of Pax3 and Pax7 drive xanthophore development in zebrafish neural crest. Minchin JE, et al. Dev Biol, 2008 May 15. PMID 18417109, Free PMC Article
  3. Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. Cruz-Garcia L, et al. J Lipid Res, 2014 Sep. PMID 25030662, Free PMC Article
  4. Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Khayrullin A, et al. Biochem Biophys Res Commun, 2016 Oct 21. PMID 27671199
  5. Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish. Quinlivan VH, et al. Front Endocrinol (Lausanne), 2017. PMID 29209275, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 3b
Names
acyl-CoA synthetase long-chain family member 3
NP_001139404.1
XP_005163605.1
XP_068080438.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145932.1 → NP_001139404.1  long-chain-fatty-acid--CoA ligase 3b

    See identical proteins and their annotated locations for NP_001139404.1

    Status: PROVISIONAL

    Source sequence(s)
    BX085193
    UniProtKB/TrEMBL
    A0A8M1NTN5, B0S5C4, F1Q8S3
    Related
    ENSDARP00000069454.6, ENSDART00000074968.6
    Conserved Domains (2) summary
    cd05927
    Location:121 → 708
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:43 → 708
    PLN02387; long-chain-fatty-acid-CoA ligase family protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    47471952..47515390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068224337.1 → XP_068080438.1  long-chain-fatty-acid--CoA ligase 3b isoform X1

  2. XM_005163548.5 → XP_005163605.1  long-chain-fatty-acid--CoA ligase 3b isoform X1

    See identical proteins and their annotated locations for XP_005163605.1

    UniProtKB/TrEMBL
    A0A8M1NTN5, B0S5C4, F1Q8S3
    Related
    ENSDARP00000113357.1, ENSDART00000141974.3
    Conserved Domains (2) summary
    cd05927
    Location:121 → 708
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:43 → 708
    PLN02387; long-chain-fatty-acid-CoA ligase family protein
Nucleotide Protein Strain
Heading Accession and Version

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