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l3mbtl1b L3MBTL histone methyl-lysine binding protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 559572, updated on 2-Nov-2024

Summary

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Official Symbol
l3mbtl1bprovided by ZNC
Official Full Name
L3MBTL histone methyl-lysine binding protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100922-38
See related
Ensembl:ENSDARG00000074346 AllianceGenome:ZFIN:ZDB-GENE-100922-38
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-108f8.2
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization and regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human L3MBTL1 (L3MBTL histone methyl-lysine binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See l3mbtl1b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (26509350..26528139, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (26637108..26654741, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1b Neighboring gene nucleolar protein 58-like Neighboring gene serum/glucocorticoid regulated kinase 2b Neighboring gene protein tyrosine phosphatase non-receptor type 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9. Feng Y, et al. G3 (Bethesda), 2016 Aug 9. PMID 27317783, Free PMC Article
  2. Concomitant duplications of opioid peptide and receptor genes before the origin of jawed vertebrates. Sundström G, et al. PLoS One, 2010 May 6. PMID 20463905, Free PMC Article
  3. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lethal(3)malignant brain tumor-like protein 4
Names
L3MBTL1, histone methyl-lysine binding protein b
l(3)mbt-like 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    26509350..26528139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_682928.10 → XP_688020.5  lethal(3)malignant brain tumor-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_688020.5

    UniProtKB/TrEMBL
    A0A8N7TAT4, E9QEX7, F1QWE7
    Related
    ENSDARP00000101801.3, ENSDART00000110260.4
    Conserved Domains (4) summary
    cd09582
    Location:716 → 781
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00454
    Location:716 → 781
    SAM; Sterile alpha motif
    smart00561
    Location:452 → 544
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:557 → 584
    zf-C2HC; Zinc finger, C2HC type

  2. XM_009292356.4 → XP_009290631.1  lethal(3)malignant brain tumor-like protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQL9
    Conserved Domains (4) summary
    cd09582
    Location:710 → 775
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00454
    Location:710 → 775
    SAM; Sterile alpha motif
    smart00561
    Location:452 → 544
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:557 → 578
    zf-C2HC; Zinc finger, C2HC type

  3. XM_009292357.4 → XP_009290632.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_009290632.1

    UniProtKB/TrEMBL
    A0A8N7TAT4, E9QEX7, F1QWE7
    Related
    ENSDARP00000121747.1, ENSDART00000134448.3
    Conserved Domains (4) summary
    cd09582
    Location:716 → 781
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00454
    Location:716 → 781
    SAM; Sterile alpha motif
    smart00561
    Location:452 → 544
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:557 → 584
    zf-C2HC; Zinc finger, C2HC type

  4. XM_068214140.1 → XP_068070241.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

RNA

  1. XR_002455794.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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