ptpn5 protein tyrosine phosphatase non-receptor type 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ptpn5provided by ZNC
Official Full Name: protein tyrosine phosphatase non-receptor type 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-101028-3
See related: Ensembl:ENSDARG00000074866 AllianceGenome:ZFIN:ZDB-GENE-101028-3
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in membrane. Predicted to be active in cell junction; cytosol; and plasma membrane. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (39624453..39661166)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (39353297..39384724)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within dephosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 5

Names: protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

XP_009301648.1

EC 3.1.3.48

XP_687962.3

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

39624453..39661166

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009303373.4 → XP_009301648.1 tyrosine-protein phosphatase non-receptor type 5

See identical proteins and their annotated locations for XP_009301648.1

UniProtKB/TrEMBL

A0A1D5NSH3, A0A8M3B4B0

Related

ENSDARP00000100744.3, ENSDART00000114774.4

Conserved Domains (2) summary

smart00194
Location:264 → 516

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:289 → 516

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_682870.7 → XP_687962.3 tyrosine-protein phosphatase non-receptor type 5

See identical proteins and their annotated locations for XP_687962.3

UniProtKB/TrEMBL

A0A1D5NSH3, A0A8M3B4B0

Related

ENSDARP00000142788.1, ENSDART00000173845.2

Conserved Domains (2) summary

smart00194
Location:264 → 516

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:289 → 516

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...