map3k20a mitogen-activated protein kinase kinase kinase 20a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: map3k20aprovided by ZNC
Official Full Name: mitogen-activated protein kinase kinase kinase 20aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070912-386
See related: Ensembl:ENSDARG00000006978 AllianceGenome:ZFIN:ZDB-GENE-070912-386
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zak; si:dkey-15i8.3
Summary: Predicted to enable MAP kinase kinase kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 9

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (2896009..2945020, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (2889989..2939000, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myofibrillar myopathy hallmarks associated with ZAK deficiency.
Title: Myofibrillar myopathy hallmarks associated with ZAK deficiency.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: mitogen-activated protein kinase kinase kinase 20

Names: sterile alpha motif and leucine zipper containing kinase AZK

NP_001314869.1

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001327940.1 → NP_001314869.1 mitogen-activated protein kinase kinase kinase 20

Status: VALIDATED

Source sequence(s)

BX004769

UniProtKB/TrEMBL

A0A8M1P394, B0S4Y7

Related

ENSDARP00000150033.1, ENSDART00000183452.1

Conserved Domains (3) summary

cd09529
Location:338 → 405

SAM_MLTK; SAM domain of MLTK subfamily

smart00221
Location:16 → 260

STYKc; Protein kinase; unclassified specificity

cl21453
Location:22 → 263

PKc_like; Protein Kinases, catalytic domain