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INKA2 inka box actin regulator 2 [ Homo sapiens (human) ]

Gene ID: 55924, updated on 5-Mar-2024

Summary

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Official Symbol
INKA2provided by HGNC
Official Full Name
inka box actin regulator 2provided by HGNC
Primary source
HGNC:HGNC:28045
See related
Ensembl:ENSG00000197852 MIM:620403; AllianceGenome:HGNC:28045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM212B; C1orf183
Summary
Enables protein kinase binding activity. Predicted to be involved in negative regulation of catalytic activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.5), heart (RPKM 3.4) and 23 other tissues See more
Orthologs
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Genomic context

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See INKA2 in Genome Data Viewer
Location:
1p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (111722064..111755797, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111736962..111770699, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112264686..112298419, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1187 Neighboring gene RNA, U6 small nuclear 151, pseudogene Neighboring gene keratin 18 pseudogene 57 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:112267545-112268314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1190 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1507 Neighboring gene uncharacterized LOC101928718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1508 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:112298273-112299157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1509 Neighboring gene INKA2 antisense RNA 1 Neighboring gene uncharacterized LOC124904312 Neighboring gene DEAD-box helicase 20 Neighboring gene potassium voltage-gated channel subfamily D member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b. Chen GL, et al. Cell Death Differ, 2021 Apr. PMID 33188281, Free PMC Article
  2. Expression profiles of inka2 in the murine nervous system. Iwasaki Y, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26292052
  3. An in cellulo-derived structure of PAK4 in complex with its inhibitor Inka1. Baskaran Y, et al. Nat Commun, 2015 Nov 26. PMID 26607847, Free PMC Article
  4. INKA2, a novel p53 target that interacts with the serine/threonine kinase PAK4. Liu YY, et al. Int J Oncol, 2019 Jun. PMID 31081062, Free PMC Article
  5. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Horikawa Y, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047128, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b.
    Title: Fra-2/AP-1 regulates melanoma cell metastasis by downregulating Fam212b.
  2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Genetic variation in MicroRNA genes and risk of oral premalignant lesions.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31105

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
PAK4-inhibitor INKA2
Names
HInca-r
family with sequence similarity 212 member B
inca-r
induced in neural crest by AP2-alpha protein-related homolog
protein FAM212B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019099.5 → NP_061972.1  PAK4-inhibitor INKA2 isoform 1

    See identical proteins and their annotated locations for NP_061972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL049557, DA306915
    Consensus CDS
    CCDS841.1
    UniProtKB/Swiss-Prot
    B3KP38, B4DF94, Q9NTI6, Q9NTI7
    Related
    ENSP00000349805.5, ENST00000357260.6
    Conserved Domains (1) summary
    pfam15342
    Location:136 → 175
    FAM212; FAM212 family

  2. NM_198926.2 → NP_945120.1  PAK4-inhibitor INKA2 isoform 2

    See identical proteins and their annotated locations for NP_945120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AL049557, AL137199
    UniProtKB/Swiss-Prot
    Q9NTI7
    UniProtKB/TrEMBL
    A0A1W2PL72
    Conserved Domains (1) summary
    pfam15342
    Location:121 → 160
    FAM212; FAM212 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    111722064..111755797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541783.3 → XP_011540085.1  PAK4-inhibitor INKA2 isoform X1

    See identical proteins and their annotated locations for XP_011540085.1

    Conserved Domains (1) summary
    pfam15342
    Location:99 → 156
    FAM212; FAM212 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    111736962..111770699 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337706.1 → XP_054193681.1  PAK4-inhibitor INKA2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NTI7.1 GenPept UniProtKB/Swiss-Prot:Q9NTI7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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