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NXT2 nuclear transport factor 2 like export factor 2 [ Homo sapiens (human) ]

Gene ID: 55916, updated on 28-Oct-2024

Summary

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Official Symbol
NXT2provided by HGNC
Official Full Name
nuclear transport factor 2 like export factor 2provided by HGNC
Primary source
HGNC:HGNC:18151
See related
Ensembl:ENSG00000101888 MIM:300320; AllianceGenome:HGNC:18151
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P15-2
Summary
The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
Expression
Broad expression in testis (RPKM 16.8), bone marrow (RPKM 5.3) and 23 other tissues See more
Orthologs
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Genomic context

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See NXT2 in Genome Data Viewer
Location:
Xq23
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (109535824..109544698)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (107983286..107992160)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (108779053..108787927)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:108590655-108591265 Neighboring gene GAPDH pseudogene 77 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:108617667-108618372 Neighboring gene guanylate cyclase 2F, retinal Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:108715324-108715825 Neighboring gene Sharpr-MPRA regulatory region 8383 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:108829413-108830382 Neighboring gene MFN1 pseudogene 1 Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Malone CF, et al. Cancer Discov, 2021 Sep. PMID 33883167, Free PMC Article
  2. TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Herold A, et al. Mol Cell Biol, 2000 Dec. PMID 11073998, Free PMC Article
  3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Zhang QH, et al. Genome Res, 2000 Oct. PMID 11042152, Free PMC Article
  5. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
part_of nuclear RNA export factor complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of nuclear RNA export factor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
NTF2-related export protein 2
Names
protein p15-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029691.1 RefSeqGene

    Range
    6064..13918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242617.2 → NP_001229546.1  NTF2-related export protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001229546.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. This results in translation initiation from a downstream AUG, and an isoform (2, also known as p15-2a) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA806876, AF201942, BC014888, DA442845
    Consensus CDS
    CCDS56605.1
    UniProtKB/Swiss-Prot
    D3DUY1, Q0VAN8, Q5JYV5, Q5JYV6, Q5JYV7, Q9H8U0, Q9NPJ8, Q9NQ64, Q9NRL7, Q9Y3M4, Q9Y3M5
    Related
    ENSP00000361178.1, ENST00000372106.6
    Conserved Domains (1) summary
    cd00780
    Location:13 → 138
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. NM_001242618.2 → NP_001229547.1  NTF2-related export protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001229547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs at the 5' end compared to variant 1. This results in translation initiation from a downstream AUG, and an isoform (3, also known as p15-2b) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA806876, AJ278323, BC014888
    Consensus CDS
    CCDS56606.1
    UniProtKB/Swiss-Prot
    Q9NPJ8
    Related
    ENSP00000361175.1, ENST00000372103.1
    Conserved Domains (1) summary
    cd00780
    Location:1 → 110
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  3. NM_018698.5 → NP_061168.2  NTF2-related export protein 2 isoform 1

    See identical proteins and their annotated locations for NP_061168.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA806876, AK023289, BC014888
    Consensus CDS
    CCDS14546.1
    UniProtKB/Swiss-Prot
    Q9NPJ8
    Related
    ENSP00000218004.1, ENST00000218004.5
    Conserved Domains (1) summary
    cd00780
    Location:68 → 193
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    109535824..109544698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530989.3 → XP_011529291.1  NTF2-related export protein 2 isoform X1

    Conserved Domains (1) summary
    cd00780
    Location:12 → 137
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. XM_017029648.3 → XP_016885137.1  NTF2-related export protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q9NPJ8
    Conserved Domains (1) summary
    cd00780
    Location:1 → 110
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    107983286..107992160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327399.1 → XP_054183374.1  NTF2-related export protein 2 isoform X1

  2. XM_054327400.1 → XP_054183375.1  NTF2-related export protein 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NPJ8.1 GenPept UniProtKB/Swiss-Prot:Q9NPJ8

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