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flrt3 fibronectin leucine rich transmembrane 3 [ Danio rerio (zebrafish) ]

Gene ID: 558864, updated on 19-Jun-2024

Summary

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Official Symbol
flrt3provided by ZNC
Official Full Name
fibronectin leucine rich transmembrane 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1988
See related
Ensembl:ENSDARG00000076895 AllianceGenome:ZFIN:ZDB-GENE-030131-1988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb93g11; wu:fb75d02; wu:fb93g11; wu:fc10a05; si:dkeyp-24h12.1
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Is expressed in several structures, including mesoderm; midbrain hindbrain boundary neural keel; nervous system; optic primordium; and optic vesicle. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 21 with or without anosmia. Orthologous to human FLRT3 (fibronectin leucine rich transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See flrt3 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (33811839..33822551, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (33685823..33696535, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene MAD2L1 binding protein Neighboring gene mono-ADP ribosylhydrolase 2 Neighboring gene epoxide hydrolase 5 Neighboring gene cystatin C (amyloid angiopathy and cerebral hemorrhage) Neighboring gene kinesin family member 16Bb Neighboring gene taspase, threonine aspartase, 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A cell surface interaction network of neural leucine-rich repeat receptors. Söllner C, et al. Genome Biol, 2009. PMID 19765300, Free PMC Article
  2. Construction of a large extracellular protein interaction network and its resolution by spatiotemporal expression profiling. Martin S, et al. Mol Cell Proteomics, 2010 Dec. PMID 20802085, Free PMC Article
  3. The impact of gene expression regulation on evolution of extracellular signaling pathways. Charoensawan V, et al. Mol Cell Proteomics, 2010 Dec. PMID 20935258, Free PMC Article
  4. Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage-specific losses. Petit D, et al. Mol Biol Evol, 2015 Apr. PMID 25534026, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat transmembrane protein FLRT3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256646.1 → NP_001243575.1  leucine-rich repeat transmembrane protein FLRT3 precursor

    Status: VALIDATED

    Source sequence(s)
    BX465200
    UniProtKB/TrEMBL
    A0A8M1NZ16, B8A507
    Related
    ENSDARP00000120607.1, ENSDART00000143703.2
    Conserved Domains (6) summary
    smart00013
    Location:31 → 61
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:305 → 356
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:104 → 327
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:61 → 84
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:85 → 105
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:247 → 306
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    33811839..33822551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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