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zp3a.2 zona pellucida glycoprotein 3a, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 558677, updated on 2-Nov-2024

Summary

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Official Symbol
zp3a.2provided by ZNC
Official Full Name
zona pellucida glycoprotein 3a, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040727-2
See related
Ensembl:ENSDARG00000042130 AllianceGenome:ZFIN:ZDB-GENE-040727-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zp3al; zpc1-2; fj87h02; wu:fj87h02; zgc:153827; si:dkey-51e6none
Summary
Predicted to enable acrosin binding activity. Predicted to be involved in binding activity of sperm to zona pellucida; egg coat formation; and positive regulation of acrosome reaction. Predicted to be located in egg coat; extracellular region; and plasma membrane. Predicted to be active in extracellular matrix. Orthologous to several human genes including ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See zp3a.2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (33987465..33989427)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (34084586..34086548)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene selectin E Neighboring gene si:dkey-51e6.1 Neighboring gene zona pellucida glycoprotein 3a, tandem duplicate 1 Neighboring gene fignl1 interacting regulator of recombination and mitosis

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish. Ota S, et al. Sci Rep, 2016 Oct 11. PMID 27725766, Free PMC Article
  2. Tandem-repeated Zebrafish zp3 genes possess oocyte-specific promoters and are insensitive to estrogen induction. Liu X, et al. Biol Reprod, 2006 Jun. PMID 16481590
  3. Induced autoimmunity against gonadal proteins affects gonadal development in juvenile zebrafish. Presslauer C, et al. PLoS One, 2014. PMID 25436775, Free PMC Article
  4. Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Wu T, et al. Fish Physiol Biochem, 2018 Apr. PMID 29307115
  5. Lamprey IGF-Binding Protein-3 Has IGF-Dependent and -Independent Actions. Zhong Y, et al. Front Endocrinol (Lausanne), 2016. PMID 28149290, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of egg coat IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in egg coat formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in egg coat IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zona pellucida sperm-binding protein 3a.2
Names
zona pellucida glycoprotein 3a.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030120.1 → NP_001025291.1  zona pellucida sperm-binding protein 3a.2 precursor

    See identical proteins and their annotated locations for NP_001025291.1

    Status: PROVISIONAL

    Source sequence(s)
    CR318619
    UniProtKB/TrEMBL
    A4FUK0, Q5TYP2
    Related
    ENSDARP00000061750.5, ENSDART00000061751.6
    Conserved Domains (2) summary
    smart00241
    Location:116 → 372
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:234 → 371
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    33987465..33989427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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