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dennd4c DENN/MADD domain containing 4C [ Danio rerio (zebrafish) ]

Gene ID: 558626, updated on 2-Nov-2024

Summary

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Official Symbol
dennd4cprovided by ZNC
Official Full Name
DENN/MADD domain containing 4Cprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120727-13
See related
Ensembl:ENSDARG00000102766 AllianceGenome:ZFIN:ZDB-GENE-120727-13
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rab protein signal transduction. Predicted to be part of ESCRT I complex. Predicted to be active in cytoplasmic vesicle. Orthologous to human DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dennd4c in Genome Data Viewer
Location:
chromosome: 7
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (59068868..59156170, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (58766438..58853983, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene FAST kinase domains 3 Neighboring gene uncharacterized LOC110439910 Neighboring gene charged multivesicular body protein 5b Neighboring gene small Cajal body-specific RNA 8 Neighboring gene HAUS augmin-like complex, subunit 6 Neighboring gene oligosaccharyltransferase complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 4C
Names
unm_sa1910

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    59068868..59156170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001919955.8 → XP_001919990.2  DENN domain-containing protein 4C isoform X2

    UniProtKB/TrEMBL
    A0A0R4IIC4, A0A8M1QKD6
    Related
    ENSDARP00000144352.1, ENSDART00000175438.2
    Conserved Domains (6) summary
    smart00801
    Location:557 → 630
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:190 → 273
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:819 → 848
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:307 → 490
    DENN; DENN (AEX-3) domain
    pfam10240
    Location:40 → 205
    DUF2464; Protein of unknown function (DUF2464)
    pfam13041
    Location:818 → 857
    PPR_2; PPR repeat family

  2. XM_005166553.5 → XP_005166610.1  DENN domain-containing protein 4C isoform X1

    UniProtKB/TrEMBL
    A0A8M2BE44
    Conserved Domains (6) summary
    smart00801
    Location:557 → 630
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:190 → 273
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    sd00004
    Location:819 → 848
    PPR; PPR repeat [structural motif]
    pfam02141
    Location:307 → 490
    DENN; DENN (AEX-3) domain
    pfam10240
    Location:40 → 205
    DUF2464; Protein of unknown function (DUF2464)
    pfam13041
    Location:818 → 857
    PPR_2; PPR repeat family
Nucleotide Protein Strain
Heading Accession and Version

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