f2r coagulation factor II (thrombin) receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: f2rprovided by ZNC
Official Full Name: coagulation factor II (thrombin) receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060526-30
See related: Ensembl:ENSDARG00000060012 AllianceGenome:ZFIN:ZDB-GENE-060526-30
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: par1; si:ch211-130m23.4
Summary: Enables thrombin-activated receptor activity. Acts upstream of or within circulatory system development; endothelial to hematopoietic transition; and negative regulation of hematopoietic stem cell differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic system; mesoderm; and pleuroperitoneal region. Orthologous to human F2R (coagulation factor II thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (46196214..46198034)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (45596061..45597881)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results demonstrate a high degree of conservation of PAR1 proteins in the vertebrate lineage in respect to amino acid sequence as well as protein function.
Title: Developmental role of zebrafish protease-activated receptor 1 (PAR1) in the cardio-vascular system.
thrombin receptor (F2r), a protease-activated G protein-coupled receptor required for vascular development, functions as a negative regulator during hematopoietic development.
Title: Thrombin receptor regulates hematopoiesis and endothelial-to-hematopoietic transition.
Par1 and Par2b are internalized following exposure to thrombin and trypsin, respectively.
Title: Identification and expression patterns of members of the protease-activated receptor (PAR) gene family during zebrafish development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables thrombin-activated receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thrombin-activated receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables thrombin-activated receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial to hematopoietic transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thrombin-activated receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within thrombin-activated receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proteinase-activated receptor 1

Names: PAR1-5A; protease-activated receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.