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WWC3 WWC family member 3 [ Homo sapiens (human) ]

Gene ID: 55841, updated on 5-Mar-2024

Summary

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Official Symbol
WWC3provided by HGNC
Official Full Name
WWC family member 3provided by HGNC
Primary source
HGNC:HGNC:29237
See related
Ensembl:ENSG00000047644 MIM:301089; AllianceGenome:HGNC:29237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BM042
Summary
This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in lung (RPKM 15.2), placenta (RPKM 10.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
Xp22.2
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (10015254..10144474)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (9597786..9727019)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (9983294..10112514)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene shroom family member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9833462-9834428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9834429-9835394 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9891645-9892144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9891143-9891644 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9895839-9896557 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:9907403-9908602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:9908687-9909186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29406 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9981409-9982292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:9982293-9983176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20655 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:10009285-10009817 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:10008750-10009284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10014897-10015530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10015531-10016163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10018119-10018742 Neighboring gene claudin 34 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10050926-10051426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10077459-10078176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:10078177-10078894 Neighboring gene Sharpr-MPRA regulatory region 7563 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:10141885-10142861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20656 Neighboring gene chloride voltage-gated channel 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:10416979-10418178 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:10476778-10477647 Neighboring gene midline 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:10539598-10539816 Neighboring gene RNA, U6 small nuclear 800, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the Wnt/β-Catenin Signaling Pathway. Wang Y, et al. DNA Cell Biol, 2018 Jan. PMID 29115863
  2. WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression. Han Q, et al. Cell Death Dis, 2021 Apr 9. PMID 33837178, Free PMC Article
  3. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Laine A, et al. Cancer Res, 2021 Aug 15. PMID 34145035, Free PMC Article
  4. Evolutionary and molecular facts link the WWC protein family to Hippo signaling. Wennmann DO, et al. Mol Biol Evol, 2014 Jul. PMID 24682284
  5. Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif. Tran THY, et al. J Mol Cell Biol, 2019 Dec 23. PMID 30865227, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
    Title: WBP2 negatively regulates the Hippo pathway by competitively binding to WWC3 with LATS1 to promote non-small cell lung cancer progression.
  2. WWC3 interacted with T cell factor 4 (TCF4).
    Title: WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the Wnt/β-Catenin Signaling Pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1280

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of hippo signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of organ growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein WWC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021467.2 RefSeqGene

    Range
    5001..133724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015691.5 → NP_056506.3  protein WWC3

    Status: VALIDATED

    Source sequence(s)
    AC002365, AC121345, KC987947
    Consensus CDS
    CCDS14136.1
    UniProtKB/Swiss-Prot
    A8KA96, Q659C1, Q9BTQ1, Q9ULE0, T2C6S4
    Related
    ENSP00000370242.6, ENST00000380861.10
    Conserved Domains (3) summary
    cd08680
    Location:727 → 850
    C2_Kibra; C2 domain found in Human protein Kibra
    pfam00397
    Location:62 → 91
    WW; WW domain
    pfam05615
    Location:127 → 244
    THOC7; Tho complex subunit 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    10015254..10144474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    9597786..9727019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULE0.4 GenPept UniProtKB/Swiss-Prot:Q9ULE0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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