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TRERF1 transcriptional regulating factor 1 [ Homo sapiens (human) ]

Gene ID: 55809, updated on 3-Apr-2024

Summary

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Official Symbol
TRERF1provided by HGNC
Official Full Name
transcriptional regulating factor 1provided by HGNC
Primary source
HGNC:HGNC:18273
See related
Ensembl:ENSG00000124496 MIM:610322; AllianceGenome:HGNC:18273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAPA; BCAR2; TREP132; TReP-132; HSA277276; dJ139D8.5
Summary
This gene encodes a zinc-finger transcriptional regulating protein which interacts with CBP/p300 to regulate the human gene CYP11A1. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in testis (RPKM 2.9), bone marrow (RPKM 2.6) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6p21.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42224931..42452224, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42053174..42280526, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42192669..42419962, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr6.2919 Neighboring gene CRISPRi-validated cis-regulatory element chr6.2920 Neighboring gene guanylate cyclase activator 1B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42183711-42184313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42184314-42184915 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24544 Neighboring gene uncharacterized LOC105375061 Neighboring gene mitochondrial ribosomal protein S10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24545 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:42209608-42210190 Neighboring gene uncharacterized LOC124901316 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr6:42225117-42225844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42227922-42228442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42228443-42228963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:42236725-42237554 Neighboring gene NANOG hESC enhancer GRCh37_chr6:42237822-42238387 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42247165-42247677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42283002-42283669 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24551 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24552 Neighboring gene uncharacterized LOC124901512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24554 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42408971-42409689 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42409690-42410407 Neighboring gene uncharacterized LOC107986596 Neighboring gene arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17204 Neighboring gene ribosomal protein L36a pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel TRERF1 mutations in Chinese patients with ovarian endometriosis. Cao B, et al. Mol Med Rep, 2018 Apr. PMID 29393434
  2. TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1. Gizard F, et al. Mol Cell Biol, 2005 Jun. PMID 15899840, Free PMC Article
  3. Identification of a novel breast-cancer-anti-estrogen-resistance (BCAR2) locus by cell-fusion-mediated gene transfer in human breast-cancer cells. Dorssers LC, et al. Int J Cancer, 1997 Aug 7. PMID 9259413
  4. TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone. Gizard F, et al. Mol Cell Biol, 2006 Oct. PMID 17015480, Free PMC Article
  5. The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells. Gizard F, et al. J Mol Endocrinol, 2004 Apr. PMID 15072559

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the present study was the first to identify 2 novel, potentially 'diseasecausing' TRERF1 somatic mutations in the endometriotic lesions in 2 out of 92 patients with ovarian endometriosis; therefore, TRERF1 mutations may be involved in the pathogenesis of ovarian endometriosis.
    Title: Novel TRERF1 mutations in Chinese patients with ovarian endometriosis.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  5. TReP-132 is a basal cell cycle regulatory protein interacting with Sp1 to activate the p21 and p27 gene promoters.
    Title: TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1.
  6. identify TReP-132 as a coactivator of progesterone receptor mediating the growth-inhibitory and differentiation effects of progesterone on breast cancer cells
    Title: TReP-132 is a novel progesterone receptor coactivator required for the inhibition of breast cancer cell growth and enhancement of differentiation by progesterone.
  7. TReP-132 interacts with steroidogenic factor-1 (SF-1) through specific domains; and along with the interaction with CBP/p300 these factors are postulated to form a complex to regulate expression of the P450scc gene.
    Title: Function of the transcriptional regulating protein of 132 kDa (TReP-132) on human P450scc gene expression.
  8. TReP-132 is a trans-acting factor of genes involved in adrenal glucocorticoid, C(19) steroid and estrogen production.
    Title: The transcriptional regulating protein of 132 kDa (TReP-132) differentially influences steroidogenic pathways in human adrenal NCI-H295 cells.
  9. TReP-132 plays a role in regulating p450scc expression with steroidogenic factor-1 and CBP/p300
    Title: The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21198

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear progesterone receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to progesterone stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcriptional-regulating factor 1
Names
breast cancer anti-estrogen resistance 2
rapa-1
rapa-2
transcriptional regulating protein 132
zinc finger protein rapa
zinc finger transcription factor TReP-132

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297573.2 → NP_001284502.1  transcriptional-regulating factor 1 isoform 1

    See identical proteins and their annotated locations for NP_001284502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AF297872, AL096814, AL450325, AM404182
    Consensus CDS
    CCDS75455.1
    UniProtKB/TrEMBL
    B3KXK2, Q05GC8
    Related
    ENSP00000439689.1, ENST00000541110.5
    Conserved Domains (5) summary
    smart00717
    Location:908 → 953
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    sd00017
    Location:1035 → 1057
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01448
    Location:801 → 855
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:909 → 953
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. NM_001391983.1 → NP_001378912.1  transcriptional-regulating factor 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL096814, AL138735, AL450325
    Consensus CDS
    CCDS4867.1
    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9
    UniProtKB/TrEMBL
    B3KXK2
    Related
    ENSP00000512292.1, ENST00000695966.1
    Conserved Domains (4) summary
    sd00017
    Location:1015 → 1037
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01448
    Location:781 → 835
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:889 → 933
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. NM_001391984.1 → NP_001378913.1  transcriptional-regulating factor 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL096814, AL138735, AL450325
    Consensus CDS
    CCDS93924.1
    UniProtKB/TrEMBL
    B3KXK2
    Conserved Domains (3) summary
    pfam01448
    Location:698 → 752
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:806 → 850
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  4. NM_001395490.1 → NP_001382419.1  transcriptional-regulating factor 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL096814, AL138735, AL450325
    Consensus CDS
    CCDS93925.1
    UniProtKB/TrEMBL
    A0A8Q3SI57, B3KXK2
    Related
    ENSP00000512293.1, ENST00000695948.1
    Conserved Domains (2) summary
    sd00018
    Location:1098 → 1120
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl21498
    Location:889 → 933
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  5. NM_033502.4 → NP_277037.1  transcriptional-regulating factor 1 isoform 2

    See identical proteins and their annotated locations for NP_277037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice donor site in the 5' coding region, compared to variant 1. Variant 2 encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AF297872, AL096814, AL450325, AM404182, AM404183
    Consensus CDS
    CCDS4867.1
    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9
    UniProtKB/TrEMBL
    B3KXK2
    Related
    ENSP00000362013.4, ENST00000372922.8
    Conserved Domains (4) summary
    sd00017
    Location:1015 → 1037
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01448
    Location:781 → 835
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:889 → 933
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    42224931..42452224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419067.1 → XP_047275023.1  transcriptional-regulating factor 1 isoform X6

  2. XM_047419061.1 → XP_047275017.1  transcriptional-regulating factor 1 isoform X5

  3. XM_047419048.1 → XP_047275004.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  4. XM_047419044.1 → XP_047275000.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  5. XM_047419033.1 → XP_047274989.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  6. XM_047419028.1 → XP_047274984.1  transcriptional-regulating factor 1 isoform X1

  7. XM_047419066.1 → XP_047275022.1  transcriptional-regulating factor 1 isoform X6

  8. XM_047419062.1 → XP_047275018.1  transcriptional-regulating factor 1 isoform X5

  9. XM_047419053.1 → XP_047275009.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  10. XM_047419041.1 → XP_047274997.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  11. XM_047419036.1 → XP_047274992.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  12. XM_047419031.1 → XP_047274987.1  transcriptional-regulating factor 1 isoform X1

  13. XM_047419055.1 → XP_047275011.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  14. XM_047419068.1 → XP_047275024.1  transcriptional-regulating factor 1 isoform X6

  15. XM_047419060.1 → XP_047275016.1  transcriptional-regulating factor 1 isoform X5

  16. XM_047419046.1 → XP_047275002.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  17. XM_047419035.1 → XP_047274991.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  18. XM_047419029.1 → XP_047274985.1  transcriptional-regulating factor 1 isoform X1

  19. XM_047419065.1 → XP_047275021.1  transcriptional-regulating factor 1 isoform X6

    Related
    ENSP00000346285.2, ENST00000354325.2

  20. XM_047419051.1 → XP_047275007.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  21. XM_047419047.1 → XP_047275003.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  22. XM_047419037.1 → XP_047274993.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  23. XM_017011054.2 → XP_016866543.1  transcriptional-regulating factor 1 isoform X6

    UniProtKB/TrEMBL
    B3KXK2
    Conserved Domains (5) summary
    smart00717
    Location:805 → 850
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    sd00017
    Location:932 → 954
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01448
    Location:698 → 752
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:806 → 850
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  24. XM_017011052.2 → XP_016866541.1  transcriptional-regulating factor 1 isoform X5

    UniProtKB/TrEMBL
    B3KXK2
    Conserved Domains (3) summary
    pfam01448
    Location:698 → 752
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:806 → 850
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  25. XM_017011049.2 → XP_016866538.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9
    UniProtKB/TrEMBL
    B3KXK2
    Conserved Domains (4) summary
    sd00017
    Location:1015 → 1037
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01448
    Location:781 → 835
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:889 → 933
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  26. XM_017011048.2 → XP_016866537.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    B3KXK2, Q05GC8
    Conserved Domains (5) summary
    smart00717
    Location:908 → 953
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    sd00017
    Location:1035 → 1057
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01448
    Location:801 → 855
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:909 → 953
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  27. XM_017011046.2 → XP_016866535.1  transcriptional-regulating factor 1 isoform X1

    UniProtKB/TrEMBL
    B3KXK2
    Conserved Domains (4) summary
    smart00717
    Location:908 → 953
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:801 → 855
    ELM2; ELM2 domain
    pfam13912
    Location:514 → 534
    zf-C2H2_6; C2H2-type zinc finger
    cl21498
    Location:909 → 953
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  28. XM_047419063.1 → XP_047275019.1  transcriptional-regulating factor 1 isoform X6

  29. XM_047419057.1 → XP_047275013.1  transcriptional-regulating factor 1 isoform X5

  30. XM_047419050.1 → XP_047275006.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  31. XM_047419039.1 → XP_047274995.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  32. XM_047419032.1 → XP_047274988.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  33. XM_047419026.1 → XP_047274982.1  transcriptional-regulating factor 1 isoform X1

  34. XM_047419054.1 → XP_047275010.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  35. XM_047419045.1 → XP_047275001.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  36. XM_047419064.1 → XP_047275020.1  transcriptional-regulating factor 1 isoform X6

  37. XM_047419058.1 → XP_047275014.1  transcriptional-regulating factor 1 isoform X5

  38. XM_047419049.1 → XP_047275005.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  39. XM_047419040.1 → XP_047274996.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  40. XM_047419034.1 → XP_047274990.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  41. XM_047419030.1 → XP_047274986.1  transcriptional-regulating factor 1 isoform X1

  42. XM_047419069.1 → XP_047275025.1  transcriptional-regulating factor 1 isoform X6

  43. XM_047419059.1 → XP_047275015.1  transcriptional-regulating factor 1 isoform X5

    Related
    ENSP00000339438.2, ENST00000340840.6

  44. XM_047419056.1 → XP_047275012.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  45. XM_047419043.1 → XP_047274999.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  46. XM_047419038.1 → XP_047274994.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  47. XM_047419027.1 → XP_047274983.1  transcriptional-regulating factor 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42053174..42280526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355918.1 → XP_054211893.1  transcriptional-regulating factor 1 isoform X6

  2. XM_054355910.1 → XP_054211885.1  transcriptional-regulating factor 1 isoform X5

  3. XM_054355898.1 → XP_054211873.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  4. XM_054355892.1 → XP_054211867.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  5. XM_054355877.1 → XP_054211852.1  transcriptional-regulating factor 1 isoform X1

  6. XM_054355917.1 → XP_054211892.1  transcriptional-regulating factor 1 isoform X6

  7. XM_054355902.1 → XP_054211877.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  8. XM_054355891.1 → XP_054211866.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  9. XM_054355885.1 → XP_054211860.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  10. XM_054355904.1 → XP_054211879.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  11. XM_054355888.1 → XP_054211863.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  12. XM_054355912.1 → XP_054211887.1  transcriptional-regulating factor 1 isoform X5

  13. XM_054355880.1 → XP_054211855.1  transcriptional-regulating factor 1 isoform X1

  14. XM_054355919.1 → XP_054211894.1  transcriptional-regulating factor 1 isoform X6

  15. XM_054355909.1 → XP_054211884.1  transcriptional-regulating factor 1 isoform X5

  16. XM_054355894.1 → XP_054211869.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  17. XM_054355884.1 → XP_054211859.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  18. XM_054355878.1 → XP_054211853.1  transcriptional-regulating factor 1 isoform X1

  19. XM_054355916.1 → XP_054211891.1  transcriptional-regulating factor 1 isoform X6

  20. XM_054355901.1 → XP_054211876.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  21. XM_054355896.1 → XP_054211871.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  22. XM_054355886.1 → XP_054211861.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  23. XM_054355913.1 → XP_054211888.1  transcriptional-regulating factor 1 isoform X6

  24. XM_054355906.1 → XP_054211881.1  transcriptional-regulating factor 1 isoform X5

  25. XM_054355897.1 → XP_054211872.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  26. XM_054355881.1 → XP_054211856.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  27. XM_054355875.1 → XP_054211850.1  transcriptional-regulating factor 1 isoform X1

  28. XM_054355914.1 → XP_054211889.1  transcriptional-regulating factor 1 isoform X6

  29. XM_054355907.1 → XP_054211882.1  transcriptional-regulating factor 1 isoform X5

  30. XM_054355900.1 → XP_054211875.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  31. XM_054355889.1 → XP_054211864.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  32. XM_054355882.1 → XP_054211857.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  33. XM_054355874.1 → XP_054211849.1  transcriptional-regulating factor 1 isoform X1

  34. XM_054355903.1 → XP_054211878.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  35. XM_054355893.1 → XP_054211868.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  36. XM_054355920.1 → XP_054211895.1  transcriptional-regulating factor 1 isoform X6

  37. XM_054355905.1 → XP_054211880.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  38. XM_054355895.1 → XP_054211870.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  39. XM_054355887.1 → XP_054211862.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  40. XM_054355911.1 → XP_054211886.1  transcriptional-regulating factor 1 isoform X5

  41. XM_054355879.1 → XP_054211854.1  transcriptional-regulating factor 1 isoform X1

  42. XM_054355915.1 → XP_054211890.1  transcriptional-regulating factor 1 isoform X6

  43. XM_054355899.1 → XP_054211874.1  transcriptional-regulating factor 1 isoform X4

    UniProtKB/Swiss-Prot
    Q05GC6, Q7Z6T2, Q7Z6T3, Q96PN7, Q9NQ72, Q9NQ73, Q9NUN9

  44. XM_054355890.1 → XP_054211865.1  transcriptional-regulating factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SI57

  45. XM_054355883.1 → XP_054211858.1  transcriptional-regulating factor 1 isoform X2

    UniProtKB/TrEMBL
    Q05GC8

  46. XM_054355908.1 → XP_054211883.1  transcriptional-regulating factor 1 isoform X5

  47. XM_054355876.1 → XP_054211851.1  transcriptional-regulating factor 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018415.1: Suppressed sequence

    Description
    NM_018415.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_033501.1: Suppressed sequence

    Description
    NM_033501.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96PN7.1 GenPept UniProtKB/Swiss-Prot:Q96PN7

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