plxna1b plexin A1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: plxna1bprovided by ZNC
Official Full Name: plexin A1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-061007-1
See related: AllianceGenome:ZFIN:ZDB-GENE-061007-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: plxna1
Summary: Predicted to enable semaphorin receptor activity. Acts upstream of or within sprouting angiogenesis and wound healing. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including nervous system; optic vesicle; otic vesicle; presumptive neural retina; and spinal cord neural tube. Orthologous to human PLXNA1 (plexin A1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (1285832..1432200, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (1348308..1354459)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003336883.1 (1956..25252, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies.
Title: Biallelic and monoallelic variants in PLXNA1 are implicated in a novel neurodevelopmental disorder with variable cerebral and eye anomalies.

Submit: New GeneRIF Correction

General gene information

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Markers

G40473 (e-PCR)
- UniSTS:12831

fc30h03.x1 (e-PCR)
- UniSTS:187948

z1701 (e-PCR), detects polymorphism
- UniSTS:205143

Z9652 (e-PCR)
- UniSTS:80749

G45810 (e-PCR)
- UniSTS:106612

z6837 (e-PCR), detects polymorphism
- UniSTS:204923

z6330 (e-PCR), detects polymorphism
- UniSTS:238244

z9652 (e-PCR), detects polymorphism
- UniSTS:238258

Z6330 (e-PCR)
- UniSTS:18161

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: plexin-A1b

Names: plexin A1; plexin A1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110010.1 → NP_001103480.1 plexin-A1b

See identical proteins and their annotated locations for NP_001103480.1

Status: PROVISIONAL

Source sequence(s)

AB262186

UniProtKB/TrEMBL

A8IYK2

Conserved Domains (8) summary

cd11271
Location:35 → 506

Sema_plexin_A1; The Sema domain, a protein interacting module, of Plexin A1

smart00423
Location:802 → 847

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:953 → 1037

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:856 → 951

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1040 → 1139

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:507 → 549

PSI; Plexin repeat

pfam01833
Location:1141 → 1224

TIG; IPT/TIG domain

pfam08337
Location:1308 → 1855

Plexin_cytopl; Plexin cytoplasmic RasGAP domain