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dnm3a dynamin 3a [ Danio rerio (zebrafish) ]

Gene ID: 557996, updated on 2-Nov-2024

Summary

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Official Symbol
dnm3aprovided by ZNC
Official Full Name
dynamin 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-76
See related
Ensembl:ENSDARG00000032238 AllianceGenome:ZFIN:ZDB-GENE-040724-76
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
dnm3; si:dkey-19f21.3
Summary
Predicted to enable GTPase activity and microtubule binding activity. Predicted to be involved in receptor internalization and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to act upstream of or within endocytosis. Predicted to be active in several cellular components, including microtubule; plasma membrane; and synapse. Is expressed in heart; liver; muscle; nervous system; and neural tube. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See dnm3a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (14819107..14924797, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (14922892..15029365, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein 5 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class C Neighboring gene microRNA 199-3a Neighboring gene microRNA 214a Neighboring gene methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Two dynamin-2 genes are required for normal zebrafish development. Gibbs EM, et al. PLoS One, 2013. PMID 23418470, Free PMC Article
  2. Evidences for a New Role of miR-214 in Chondrogenesis. Roberto VP, et al. Sci Rep, 2018 Feb 27. PMID 29487295, Free PMC Article
  3. Evolution of the miR199-214 cluster and vertebrate skeletal development. Desvignes T, et al. RNA Biol, 2014. PMID 24643020, Free PMC Article
  4. Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Biswas G, et al. Mar Genomics, 2015 Aug. PMID 25792259
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dynamin 3a
Names
dynamin 3
NP_001121996.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128524.1 → NP_001121996.1  dynamin 3a

    See identical proteins and their annotated locations for NP_001121996.1

    Status: PROVISIONAL

    Source sequence(s)
    BX470128
    UniProtKB/TrEMBL
    A0A8M1NHL4, Q5RHR9, R4GE56
    Related
    ENSDARP00000047038.6, ENSDART00000047039.7
    Conserved Domains (6) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:78 → 502
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:514 → 625
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:516 → 619
    PH; PH domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:647 → 730
    GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    14819107..14924797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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