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haspin histone H3 associated protein kinase [ Danio rerio (zebrafish) ]

Gene ID: 557879, updated on 18-Sep-2024

Summary

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Official Symbol
haspinprovided by ZNC
Official Full Name
histone H3 associated protein kinaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-090313-379
See related
Ensembl:ENSDARG00000092290 AllianceGenome:ZFIN:ZDB-GENE-090313-379
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkeyp-26a9.2
Summary
Predicted to enable histone kinase activity (H3-T3 specific). Predicted to be involved in intracellular signal transduction and mitotic cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See haspin in Genome Data Viewer
Location:
chromosome: 1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (23489239..23507710)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22800207..22816208)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene transfer RNA arginine (anticodon CCG) Neighboring gene family with sequence similarity 184 member B Neighboring gene non-SMC condensin I complex, subunit G Neighboring gene ligand dependent nuclear receptor corepressor-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation. Quadri R, et al. Int J Mol Sci, 2021 Jul 20. PMID 34299370, Free PMC Article
  2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3T3 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase haspin
XP_017211541.2
XP_021329574.1
XP_021330260.2
XP_021331582.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    23489239..23507710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021475907.2 → XP_021331582.2  serine/threonine-protein kinase haspin

    Related
    ENSDARP00000118059.1, ENSDART00000134576.2

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394481.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    198700..221337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017356052.3 → XP_017211541.2  serine/threonine-protein kinase haspin

    UniProtKB/TrEMBL
    A0A8M6YZ20
    Conserved Domains (1) summary
    cl26373
    Location:773 → 1071
    DUF3635; Domain of unknown function (DUF3635)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395215.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    26782..46190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473899.2 → XP_021329574.1  serine/threonine-protein kinase haspin

    UniProtKB/TrEMBL
    A0A8M9PXH5
    Conserved Domains (1) summary
    cl26373
    Location:773 → 1071
    DUF3635; Domain of unknown function (DUF3635)

Reference GRCz11 ALT_DRER_TU_3

Genomic

  1. NW_018395373.1 Reference GRCz11 ALT_DRER_TU_3

    Range
    35773..53050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021474585.2 → XP_021330260.2  serine/threonine-protein kinase haspin

Nucleotide Protein Strain
Heading Accession and Version

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