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mapre2 microtubule-associated protein, RP/EB family, member 2 [ Danio rerio (zebrafish) ]

Gene ID: 557679, updated on 19-Jun-2024

Summary

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Official Symbol
mapre2provided by ZNC
Official Full Name
microtubule-associated protein, RP/EB family, member 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-071004-41
See related
Ensembl:ENSDARG00000099943 AllianceGenome:ZFIN:ZDB-GENE-071004-41
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:171788
Summary
Predicted to enable microtubule plus-end binding activity. Acts upstream of or within embryonic cranial skeleton morphogenesis. Predicted to be located in cytoplasm and microtubule. Predicted to be active in microtubule cytoskeleton. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE2 (microtubule associated protein RP/EB family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mapre2 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (35679091..35707549, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (35790997..35819452, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene CCAAT enhancer binding protein delta Neighboring gene scaffold protein involved in DNA repair Neighboring gene dystrobrevin, alpha Neighboring gene uncharacterized LOC110438360 Neighboring gene coiled-coil domain containing 178

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type. Isrie M, et al. Am J Hum Genet, 2015 Dec 3. PMID 26637975, Free PMC Article
  2. Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs. Marchal GA, et al. Circ Res, 2021 Jul 23. PMID 34092082, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction.
    Title: The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
microtubule-associated protein RP/EB family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109702.1 → NP_001103172.1  microtubule-associated protein RP/EB family member 2

    See identical proteins and their annotated locations for NP_001103172.1

    Status: PROVISIONAL

    Source sequence(s)
    BC151983
    UniProtKB/TrEMBL
    A0A0R4IRK9, A0A8M1NEW8, A7MC00
    Related
    ENSDARP00000137205.2, ENSDART00000166567.2
    Conserved Domains (3) summary
    COG5217
    Location:60 → 326
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
    pfam00307
    Location:60 → 144
    CH; Calponin homology (CH) domain
    pfam03271
    Location:270 → 307
    EB1; EB1-like C-terminal motif

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    35679091..35707549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162865.4 → XP_005162922.1  microtubule-associated protein RP/EB family member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BA49
    Conserved Domains (3) summary
    COG5217
    Location:16 → 282
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
    pfam00307
    Location:16 → 100
    CH; Calponin homology (CH) domain
    pfam03271
    Location:226 → 263
    EB1; EB1-like C-terminal motif

  2. XM_009297591.3 → XP_009295866.1  microtubule-associated protein RP/EB family member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AW64
    Related
    ENSDARP00000138793.1, ENSDART00000167990.2
    Conserved Domains (3) summary
    COG5217
    Location:60 → 326
    BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
    pfam00307
    Location:60 → 144
    CH; Calponin homology (CH) domain
    pfam03271
    Location:270 → 307
    EB1; EB1-like C-terminal motif
Nucleotide Protein Strain
Heading Accession and Version

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