U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 [ Danio rerio (zebrafish) ]

Gene ID: 557602, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
dyrk2provided by ZNC
Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2804
See related
Ensembl:ENSDARG00000094646 AllianceGenome:ZFIN:ZDB-GENE-030131-2804
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc18c09; wu:fa09g03; wu:fc18c09; si:ch211-266a5.8
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in central nervous system; myotome; and spinal cord. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dyrk2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (13450011..13461599)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (13451009..13462742)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene cullin-associated and neddylation-dissociated 1 Neighboring gene si:dkey-39a18.1 Neighboring gene si:ch211-266a5.12 Neighboring gene interferon gamma 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis. Sun W, et al. Int J Dev Biol, 2017. PMID 28695966
  2. Analysis of the dynamic co-expression network of heart regeneration in the zebrafish. Rodius S, et al. Sci Rep, 2016 May 31. PMID 27241320, Free PMC Article
  3. Phosphorylation of Dpsyl2 (CRMP2) and Dpsyl3 (CRMP4) is required for positioning of caudal primary motor neurons in the zebrafish spinal cord. Morimura R, et al. Dev Neurobiol, 2013 Dec. PMID 23929741
  4. An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Igawa D, et al. Mol Immunol, 2006 Mar. PMID 16005068
  5. Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish. Tanaka H, et al. Dev Biol, 2012 Oct 15. PMID 22898304

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data indicate that DYRK2 is expressed in the developing muscle progenitor cells in somites and that it positively regulates fast-twitch muscle differentiation, at least at the early stages
    Title: DYRK2 displays muscle fiber type specific function during zebrafish early somitogenesis.
  2. These results suggest that the phosphorylation of Dpysl2 and Dpysl3 by Cdk5 and DYRK2 is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.
    Title: Dpysl2 (CRMP2) and Dpysl3 (CRMP4) phosphorylation by Cdk5 and DYRK2 is required for proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 2
NP_001038298.1
XP_005164697.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044833.2 → NP_001038298.1  dual specificity tyrosine-phosphorylation-regulated kinase 2

    See identical proteins and their annotated locations for NP_001038298.1

    Status: PROVISIONAL

    Source sequence(s)
    BC139631
    UniProtKB/TrEMBL
    A4QP29, Q5RHV3
    Related
    ENSDARP00000122944.1, ENSDART00000145069.2
    Conserved Domains (2) summary
    smart00220
    Location:209 → 522
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:143 → 522
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    13450011..13461599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164640.5 → XP_005164697.1  dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform X1

    UniProtKB/TrEMBL
    A0A0R4ITS5, A0A8M2BBR5
    Related
    ENSDARP00000140216.1, ENSDART00000172552.2
    Conserved Domains (2) summary
    smart00220
    Location:220 → 533
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14224
    Location:154 → 533
    PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools