kirrel3l kirre like nephrin family adhesion molecule 3, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kirrel3lprovided by ZNC
Official Full Name: kirre like nephrin family adhesion molecule 3, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070831-1
See related: Ensembl:ENSDARG00000104665 AllianceGenome:ZFIN:ZDB-GENE-070831-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb33; kirrel3; sb:cb33; wu:fb74e02; si:dkey-29g23.1
Summary: Predicted to enable cell adhesion molecule binding activity. Acts upstream of or within brain development; kidney development; and myoblast fusion. Located in plasma membrane. Is expressed in several structures, including axial mesoderm; brain; neural tube; pronephros; and sensory system. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (36941455..37027289)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (37039877..37114456)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the expression of neph3 in glomerulus and brain imply that neph3 is a pleiotropic gene active during distinct stages of tissue differentiation and associates directly in the regulation of both glomerular and neural development.
Title: Neph3 associates with regulation of glomerular and neural development in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fc30f10.x1 (e-PCR)
- UniSTS:187943

fd11d08.x1 (e-PCR)
- UniSTS:195139

fb74e02.x1 (e-PCR)
- UniSTS:187471

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glomerular basement membrane development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within podocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephric glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kin of IRRE-like protein 2; kirre like nephrin family adhesion molecule 3, like

Names: Neph2c; kin of IRRE like 3 like; kirrel2; neph3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099344.2 → NP_001092814.2 kirre like nephrin family adhesion molecule 3, like precursor

Status: VALIDATED

Source sequence(s)

AL953844, CR848678

UniProtKB/TrEMBL

A0A0R4IT86, A0A8M1NF10

Related

ENSDARP00000139126.1, ENSDART00000172664.2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007126.7 Reference GRCz11 Primary Assembly

Range

36941455..37027289

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021481418.1 → XP_021337093.1 kin of IRRE-like protein 2 isoform X1

UniProtKB/TrEMBL

A0A8M9QC09

Conserved Domains (4) summary

cd05759
Location:135 → 216

Ig2_KIRREL3-like; Second immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2)

pfam13895
Location:223 → 302

Ig_2; Immunoglobulin domain

cd05758
Location:388 → 485

Ig5_KIRREL3-like; Fifth immunoglobulin (Ig)-like domain of Kirrel (kin of irregular chiasm-like) 3 (also known as Neph2) and similar proteins

cl28434
Location:305 → 386

I-set; Immunoglobulin I-set domain