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sptlc2b serine palmitoyltransferase, long chain base subunit 2b [ Danio rerio (zebrafish) ]

Gene ID: 557286, updated on 28-Oct-2024

Summary

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Official Symbol
sptlc2bprovided by ZNC
Official Full Name
serine palmitoyltransferase, long chain base subunit 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-080305-8
See related
Ensembl:ENSDARG00000074287 AllianceGenome:ZFIN:ZDB-GENE-080305-8
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:175221
Summary
Predicted to enable serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to act upstream of or within biosynthetic process. Predicted to be located in membrane. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See sptlc2b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (5330539..5369105, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (5286132..5324698, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3 Neighboring gene isthmin 2b Neighboring gene SNW domain containing 1 Neighboring gene neurexin 3b Neighboring gene uncharacterized LOC137488611

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Zhang T, et al. Sci Rep, 2019 Dec 27. PMID 31882772, Free PMC Article
  2. Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Qiu W, et al. Ecotoxicol Environ Saf, 2019 Jun 15. PMID 30826544
  3. Multiple thyrotropin β-subunit and thyrotropin receptor-related genes arose during vertebrate evolution. Maugars G, et al. PLoS One, 2014. PMID 25386660, Free PMC Article
  4. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC175221

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables serine C-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of serine palmitoyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine palmitoyltransferase 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114741.1 → NP_001108213.1  serine palmitoyltransferase 2b

    See identical proteins and their annotated locations for NP_001108213.1

    Status: PROVISIONAL

    Source sequence(s)
    BC159260
    UniProtKB/TrEMBL
    B0JZN8
    Related
    ENSDARP00000103258.2, ENSDART00000114316.5
    Conserved Domains (2) summary
    PLN02483
    Location:66 → 540
    PLN02483; serine palmitoyltransferase
    COG0156
    Location:116 → 531
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    5330539..5369105 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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