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enc2 ectodermal-neural cortex 2 [ Danio rerio (zebrafish) ]

Gene ID: 556885, updated on 12-Sep-2024

Summary

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Official Symbol
enc2provided by ZNC
Official Full Name
ectodermal-neural cortex 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-131014-1
See related
Ensembl:ENSDARG00000102418 AllianceGenome:ZFIN:ZDB-GENE-131014-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
klhl25
Summary
Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within regulation of translational initiation. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in central nervous system; presumptive rhombomere 3; presumptive rhombomere 5; tail bud; and trunk. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See enc2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (11357408..11383920, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (11263726..11287137, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2Bb Neighboring gene A-kinase anchoring protein 13 Neighboring gene AGBL carboxypeptidase 1 Neighboring gene uncharacterized LOC137489331 Neighboring gene uncharacterized LOC137489333 Neighboring gene neurotrophic tyrosine kinase, receptor, type 3a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch-like protein 25
Names
kelch like family member 25

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    11357408..11383920 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009297853.4 → XP_009296128.1  kelch-like protein 25 isoform X2

    UniProtKB/TrEMBL
    A0A0G2KCH4, A0A8M3APK6
    Related
    ENSDARP00000129983.2, ENSDART00000166586.2
    Conserved Domains (6) summary
    smart00612
    Location:389 → 441
    Kelch; Kelch domain
    PHA03098
    Location:39 → 566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 374
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:36 → 140
    BTB; BTB/POZ domain
    pfam01344
    Location:329 → 374
    Kelch_1; Kelch motif
    pfam07707
    Location:149 → 231
    BACK; BTB And C-terminal Kelch

  2. XM_009297852.4 → XP_009296127.1  kelch-like protein 25 isoform X1

    See identical proteins and their annotated locations for XP_009296127.1

    UniProtKB/TrEMBL
    A0A8M3B706
    Conserved Domains (6) summary
    smart00612
    Location:425 → 477
    Kelch; Kelch domain
    PHA03098
    Location:75 → 602
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:366 → 410
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:72 → 176
    BTB; BTB/POZ domain
    pfam01344
    Location:365 → 410
    Kelch_1; Kelch motif
    pfam07707
    Location:185 → 267
    BACK; BTB And C-terminal Kelch
Nucleotide Protein Strain
Heading Accession and Version

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