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PRPF40A pre-mRNA processing factor 40 homolog A [ Homo sapiens (human) ]

Gene ID: 55660, updated on 7-Apr-2024

Summary

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Official Symbol
PRPF40Aprovided by HGNC
Official Full Name
pre-mRNA processing factor 40 homolog Aprovided by HGNC
Primary source
HGNC:HGNC:16463
See related
Ensembl:ENSG00000196504 MIM:612941; AllianceGenome:HGNC:16463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HYPA; FBP11; FLAF1; FNBP3; HIP10; Prp40; FBP-11; HIP-10; NY-REN-6
Summary
Enables RNA binding activity. Involved in several processes, including cytoskeleton organization; regulation of cell shape; and regulation of cytokinesis. Located in nuclear matrix and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 15.6), testis (RPKM 13.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2q23.3
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (152651732..152718019, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (153104294..153170565, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (153508246..153574533, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373689 Neighboring gene uncharacterized LOC105373688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153183153-153183652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12012 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153258063-153258564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153258565-153259064 Neighboring gene Sharpr-MPRA regulatory region 2662 Neighboring gene formin like 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:153280187-153280913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153280914-153281639 Neighboring gene Sharpr-MPRA regulatory region 469 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:153309665-153310256 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:153310257-153310847 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:153312623-153313213 Neighboring gene nuclear distribution C pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:153357706-153358281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16649 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:153474731-153475930 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:153502126-153503325 Neighboring gene NANOG hESC enhancer GRCh37_chr2:153508427-153509132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:153519134-153520333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16650 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:153557503-153558702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:153558975-153559476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16655 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:153574523-153575228 Neighboring gene ADP ribosylation factor like GTPase 6 interacting protein 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:153661367-153661578 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:153702825-153704024 Neighboring gene ubiquilin 4 pseudogene 2 Neighboring gene uncharacterized LOC105373691 Neighboring gene NANOG hESC enhancer GRCh37_chr2:153842337-153842838

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The effect of C-terminal helix on the stability of FF domain studied by molecular dynamics simulation. Zhao L, et al. Int J Mol Sci, 2012. PMID 22408419, Free PMC Article
  2. A transient and low-populated protein-folding intermediate at atomic resolution. Korzhnev DM, et al. Science, 2010 Sep 10. PMID 20829478
  3. Structure of FBP11 WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains. Kato Y, et al. J Biol Chem, 2006 Dec 29. PMID 17065151
  4. Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA). Jiang YJ, et al. J Biol Chem, 2011 Jul 15. PMID 21566141, Free PMC Article
  5. The structure of an FF domain from human HYPA/FBP11. Allen M, et al. J Mol Biol, 2002 Oct 25. PMID 12381297

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our data revealed that COL1A1, UCP2, and PRPF40A are novel players implicated in the complex network of hypoxia response in non-small cell lung cancer
    Title: COL1A1, PRPF40A, and UCP2 correlate with hypoxia markers in non-small cell lung cancer.
  2. Multidisciplinary approach showed that HsPrp40Ap interacts with centrin in vitro, supporting a coupled functional role for these proteins in pre-mRNA splicing.
    Title: Prp40 Homolog A Is a Novel Centrin Target.
  3. Study of native domain FF3-71 from human HYPA/FBP11 and the truncated version FF3-60 with C-terminal helix being deleted by molecular dynamics simulations.
    Title: The effect of C-terminal helix on the stability of FF domain studied by molecular dynamics simulation.
  4. Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA).
    Title: Interaction with polyglutamine-expanded huntingtin alters cellular distribution and RNA processing of huntingtin yeast two-hybrid protein A (HYPA).
  5. an atomic-resolution structure of an "invisible" folding intermediate of a small protein module: the FF domain; structure reveals non-native elements preventing formation of native conformation in the carboxyl-terminal part of the protein
    Title: A transient and low-populated protein-folding intermediate at atomic resolution.
  6. FBP11 binding mechanism underlies the molecular pathology of severe neurological disorders, e.g., Rett syndrome and Huntington disease.
    Title: Structure of FBP11 WW1-PL ligand complex reveals the mechanism of proline-rich ligand recognition by group II/III WW domains.
  7. NAKAP-HypA scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in HD.
    Title: Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis.
  8. Results suggest an essential role of WW/FF domain-containing factors such as FBP11 and CA150 in pre-mRNA splicing that likely occurs in concert with transcription in vivo.
    Title: The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo.
  9. Data describe the structure of an FF domain from HYPA/FBP11, which differs from those of other phosphopeptide-binding domains and represents a novel phosphopeptide-binding fold.
    Title: The structure of an FF domain from human HYPA/FBP11.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify PRP40 pre-Mrna processing factor 40 homolog A (PRPF40A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify PRP40 pre-mRNA processing factor 40 homolog A (PRPF40A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify PRP40 pre-Mrna processing factor 40 homolog A (PRPF40A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify PRP40 pre-Mrna processing factor 40 homolog A (PRPF40A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20585

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
pre-mRNA-processing factor 40 homolog A
Names
Fas-ligand associated factor 1
Huntingtin-interacting protein A
NY-REN-6 antigen
PRP40 pre-mRNA processing factor 40 homolog A
fas ligand-associated factor 1
formin binding protein 3
formin-binding protein 11
huntingtin yeast partner A
huntingtin-interacting protein 10
renal carcinoma antigen NY-REN-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001354431.4 → NP_001341360.1  pre-mRNA-processing factor 40 homolog A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:110 → 751
    PRP40; Splicing factor [RNA processing and modification]

  2. NM_001354432.4 → NP_001341361.1  pre-mRNA-processing factor 40 homolog A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    cl00157
    Location:38 → 701
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  3. NM_001365596.4 → NP_001352525.1  pre-mRNA-processing factor 40 homolog A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/Swiss-Prot
    O43856, O75400, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8
    Conserved Domains (1) summary
    cl00157
    Location:152 → 815
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  4. NM_001365597.4 → NP_001352526.1  pre-mRNA-processing factor 40 homolog A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    Consensus CDS
    CCDS92876.1
    UniProtKB/Swiss-Prot
    O43856, O75400, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8
    UniProtKB/TrEMBL
    F5H578
    Related
    ENSP00000444656.4, ENST00000545856.8
    Conserved Domains (1) summary
    cl00157
    Location:152 → 811
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  5. NM_001365598.4 → NP_001352527.1  pre-mRNA-processing factor 40 homolog A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/Swiss-Prot
    O43856, O75400, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8
    Conserved Domains (1) summary
    cl00157
    Location:152 → 797
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  6. NM_001365599.4 → NP_001352528.1  pre-mRNA-processing factor 40 homolog A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/Swiss-Prot
    O43856, O75400, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8
    Conserved Domains (1) summary
    cl00157
    Location:152 → 793
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  7. NM_001365600.4 → NP_001352529.1  pre-mRNA-processing factor 40 homolog A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    Consensus CDS
    CCDS92878.1
    UniProtKB/TrEMBL
    A0A8V8TM61, A0A8V8TM87
    Related
    ENSP00000513920.1, ENST00000698772.1
    Conserved Domains (1) summary
    COG5104
    Location:110 → 773
    PRP40; Splicing factor [RNA processing and modification]

  8. NM_001365601.4 → NP_001352530.1  pre-mRNA-processing factor 40 homolog A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:110 → 755
    PRP40; Splicing factor [RNA processing and modification]

  9. NM_001365602.4 → NP_001352531.1  pre-mRNA-processing factor 40 homolog A isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    cl00157
    Location:54 → 717
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  10. NM_001365603.4 → NP_001352532.1  pre-mRNA-processing factor 40 homolog A isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:54 → 713
    PRP40; Splicing factor [RNA processing and modification]

  11. NM_001365604.4 → NP_001352533.1  pre-mRNA-processing factor 40 homolog A isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:54 → 695
    PRP40; Splicing factor [RNA processing and modification]

  12. NM_001365605.4 → NP_001352534.1  pre-mRNA-processing factor 40 homolog A isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:54 → 695
    PRP40; Splicing factor [RNA processing and modification]

  13. NM_001395472.1 → NP_001382401.1  pre-mRNA-processing factor 40 homolog A isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    Consensus CDS
    CCDS92878.1
    UniProtKB/TrEMBL
    A0A8V8TM61, A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:110 → 773
    PRP40; Splicing factor [RNA processing and modification]

  14. NM_001395473.1 → NP_001382402.1  pre-mRNA-processing factor 40 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:110 → 769
    PRP40; Splicing factor [RNA processing and modification]

  15. NM_001395475.1 → NP_001382404.1  pre-mRNA-processing factor 40 homolog A isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:95 → 758
    PRP40; Splicing factor [RNA processing and modification]

  16. NM_001395476.1 → NP_001382405.1  pre-mRNA-processing factor 40 homolog A isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:110 → 755
    PRP40; Splicing factor [RNA processing and modification]

  17. NM_001395477.1 → NP_001382406.1  pre-mRNA-processing factor 40 homolog A isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    Consensus CDS
    CCDS92877.1
    UniProtKB/TrEMBL
    A0A8Q3SIG7, A0A8V8TM87
    Related
    ENSP00000512592.1, ENST00000696382.1
    Conserved Domains (1) summary
    COG5104
    Location:95 → 754
    PRP40; Splicing factor [RNA processing and modification]

  18. NM_001395478.1 → NP_001382407.1  pre-mRNA-processing factor 40 homolog A isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    Consensus CDS
    CCDS92877.1
    UniProtKB/TrEMBL
    A0A8Q3SIG7, A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:95 → 754
    PRP40; Splicing factor [RNA processing and modification]

  19. NM_001395479.1 → NP_001382408.1  pre-mRNA-processing factor 40 homolog A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:110 → 751
    PRP40; Splicing factor [RNA processing and modification]

  20. NM_001395480.1 → NP_001382409.1  pre-mRNA-processing factor 40 homolog A isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (3) summary
    PHA03255
    Location:165 → 307
    PHA03255; BDLF3; Provisional
    COG5104
    Location:298 → 716
    PRP40; Splicing factor [RNA processing and modification]
    cd00201
    Location:104 → 134
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  21. NM_001395481.1 → NP_001382410.1  pre-mRNA-processing factor 40 homolog A isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:54 → 713
    PRP40; Splicing factor [RNA processing and modification]

  22. NM_001395482.1 → NP_001382411.1  pre-mRNA-processing factor 40 homolog A isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:54 → 699
    PRP40; Splicing factor [RNA processing and modification]

  23. NM_001395483.1 → NP_001382412.1  pre-mRNA-processing factor 40 homolog A isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (2) summary
    smart00441
    Location:617 → 671
    FF; Contains two conserved F residues
    COG5104
    Location:6 → 554
    PRP40; Splicing factor [RNA processing and modification]

  24. NM_001395488.1 → NP_001382417.1  pre-mRNA-processing factor 40 homolog A isoform 18

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25) encodes the longest isoform (18).
    Source sequence(s)
    AC012443, AC079344
    Consensus CDS
    CCDS92879.1
    UniProtKB/TrEMBL
    A0A7N4I394, A0A8V8TM87
    Related
    ENSP00000386458.4, ENST00000410080.8
    Conserved Domains (1) summary
    COG5104
    Location:174 → 833
    PRP40; Splicing factor [RNA processing and modification]

  25. NM_017892.5 → NP_060362.3  pre-mRNA-processing factor 40 homolog A isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC012443, AC079344
    UniProtKB/TrEMBL
    A0A8V8TM87
    Conserved Domains (1) summary
    COG5104
    Location:110 → 769
    PRP40; Splicing factor [RNA processing and modification]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    152651732..152718019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444942.1 → XP_047300898.1  pre-mRNA-processing factor 40 homolog A isoform X3

  2. XM_047444941.1 → XP_047300897.1  pre-mRNA-processing factor 40 homolog A isoform X2

    Related
    ENSP00000513921.1, ENST00000698773.1

  3. XM_011511447.4 → XP_011509749.2  pre-mRNA-processing factor 40 homolog A isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    153104294..153170565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342878.1 → XP_054198853.1  pre-mRNA-processing factor 40 homolog A isoform X3

  2. XM_054342877.1 → XP_054198852.1  pre-mRNA-processing factor 40 homolog A isoform X2

  3. XM_054342876.1 → XP_054198851.1  pre-mRNA-processing factor 40 homolog A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75400.2 GenPept UniProtKB/Swiss-Prot:O75400

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