U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

rdh5 retinol dehydrogenase 5 (11-cis/9-cis) [ Danio rerio (zebrafish) ]

Gene ID: 556528, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
rdh5provided by ZNC
Official Full Name
retinol dehydrogenase 5 (11-cis/9-cis)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-411
See related
Ensembl:ENSDARG00000008306 AllianceGenome:ZFIN:ZDB-GENE-050208-411
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hsd17b9; im:6901729; si:dkey-102c8.5
Summary
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within eye photoreceptor cell differentiation; retina development in camera-type eye; and vitamin A biosynthetic process. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including gut; heart; pineal complex; skeletal muscle cell; and visual system. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See rdh5 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (10112099..10122593, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (10083174..10093034, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108181084 Neighboring gene glutaminase 2b (liver, mitochondrial) Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene TBC1 domain family, member 20

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Comparative genomic and phylogenetic analysis of short-chain dehydrogenases/reductases with dual retinol/sterol substrate specificity. Belyaeva OV, et al. Genomics, 2006 Dec. PMID 16860536
  2. Phenotypic and transcriptomic consequences in zebrafish early-life stages following exposure to crude oil and chemical dispersant at sublethal concentrations. Li X, et al. Sci Total Environ, 2021 Apr 1. PMID 33129528
  3. Identification of differentially expressed genes during development of the zebrafish pineal complex using RNA sequencing. Khuansuwan S, et al. Dev Biol, 2014 Nov 1. PMID 25173875, Free PMC Article
  4. The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation. Chen DD, et al. FASEB J, 2023 Mar. PMID 36826429
  5. Genetic hyperactivation of Nrf2 causes larval lethality in Keap1a and Keap1b-double-knockout zebrafish. Bian L, et al. Redox Biol, 2023 Jun. PMID 36934645, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC114091

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within eye photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in retinoid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vitamin A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
retinol dehydrogenase 5
NP_001025272.1
XP_005174018.1
XP_009294380.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030101.1 → NP_001025272.1  retinol dehydrogenase 5

    See identical proteins and their annotated locations for NP_001025272.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097151
    UniProtKB/TrEMBL
    Q4V8Y1
    Related
    ENSDARP00000013032.7, ENSDART00000002348.9
    Conserved Domains (2) summary
    pfam00106
    Location:40 → 224
    adh_short; short chain dehydrogenase
    cl21454
    Location:40 → 314
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    10112099..10122593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173961.5 → XP_005174018.1  retinol dehydrogenase 5 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BLL9
    Related
    ENSDARP00000107807.2, ENSDART00000128590.3
    Conserved Domains (2) summary
    pfam00106
    Location:38 → 222
    adh_short; short chain dehydrogenase
    cl21454
    Location:38 → 312
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_009296105.4 → XP_009294380.1  retinol dehydrogenase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AM49, F1RCW4
    Related
    ENSDARP00000143810.1, ENSDART00000177475.2
    Conserved Domains (2) summary
    pfam00106
    Location:40 → 224
    adh_short; short chain dehydrogenase
    cl21454
    Location:40 → 314
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.