U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sh3rf1 SH3 domain containing ring finger 1 [ Danio rerio (zebrafish) ]

Gene ID: 556523, updated on 2-Nov-2024

Summary

Official Symbol
sh3rf1provided by ZNC
Official Full Name
SH3 domain containing ring finger 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-6288
See related
Ensembl:ENSDARG00000070470 AllianceGenome:ZFIN:ZDB-GENE-030131-6288
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi42f11; wu:fi42f11; si:dkey-15j16.4; si:ch211-114c9.2
Summary
Predicted to enable MAP-kinase scaffold activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of alpha-beta T cell activation. Predicted to be located in lamellipodium. Orthologous to human SH3RF1 (SH3 domain containing ring finger 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See sh3rf1 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (23742574..23836967)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (23843474..23937867)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene si:ch211-191d2.2 Neighboring gene NIMA-related kinase 1 Neighboring gene si:dkey-15j16.3 Neighboring gene si:dkey-15j16.6

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC162767

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of CD4-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of CD8-positive, alpha-beta T cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SH3RF1
Names
RING-type E3 ubiquitin transferase SH3RF1
SH3 domain-containing RING finger protein 1
plenty of SH3s
putative E3 ubiquitin-protein ligase SH3RF1
NP_001038257.1
NP_001038952.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044792.1NP_001038257.1  E3 ubiquitin-protein ligase SH3RF1 isoform 2

    Status: PROVISIONAL

    Source sequence(s)
    BX255904
    UniProtKB/Swiss-Prot
    A5D8S5
    UniProtKB/TrEMBL
    A0A8M1N9B8
    Conserved Domains (5) summary
    cd11785
    Location:802856
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11926
    Location:467521
    SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
    cd11927
    Location:174227
    SH3_SH3RF1_1; First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd11930
    Location:237291
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd00162
    Location:2469
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_001045487.2NP_001038952.2  E3 ubiquitin-protein ligase SH3RF1 isoform 1

    See identical proteins and their annotated locations for NP_001038952.2

    Status: PROVISIONAL

    Source sequence(s)
    BC141794
    UniProtKB/Swiss-Prot
    A5D8S5
    UniProtKB/TrEMBL
    B3DIT8
    Related
    ENSDARP00000050558.5, ENSDART00000050559.7
    Conserved Domains (5) summary
    cd11785
    Location:825879
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11926
    Location:453507
    SH3_SH3RF1_3; Third Src Homology 3 domain of SH3 domain containing ring finger 1, an E3 ubiquitin-protein ligase
    cd11927
    Location:148201
    SH3_SH3RF1_1; First Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd11930
    Location:211265
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd00162
    Location:2469
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    23742574..23836967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)