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adma adrenomedullin a [ Danio rerio (zebrafish) ]

Gene ID: 556502, updated on 2-Nov-2024

Summary

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Official Symbol
admaprovided by ZNC
Official Full Name
adrenomedullin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-120221-5
See related
Ensembl:ENSDARG00000015263 AllianceGenome:ZFIN:ZDB-GENE-120221-5
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable adrenomedullin receptor binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; positive regulation of heart rate; and regulation of systemic arterial blood pressure. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in epicardium. Human ortholog(s) of this gene implicated in brain infarction; breast cancer; pancreatic cancer; and pulmonary hypertension. Orthologous to human ADM (adrenomedullin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See adma in Genome Data Viewer
Location:
chromosome: 7
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (66874763..66876959, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (66651115..66653311, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene lymphatic vessel endothelial hyaluronic receptor 1a Neighboring gene adenosine monophosphate deaminase 3a Neighboring gene SET binding factor 2 Neighboring gene switching B cell complex subunit SWAP70a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites. Tsaryk R, et al. Sci Rep, 2022 Mar 21. PMID 35314737, Free PMC Article
  2. Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation. Karampelias C, et al. Nat Commun, 2021 Jun 7. PMID 34099692, Free PMC Article
  3. Functional Heterogeneity within the Developing Zebrafish Epicardium. Weinberger M, et al. Dev Cell, 2020 Mar 9. PMID 32084358, Free PMC Article
  4. IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation. Lu J, et al. EMBO J, 2016 Sep 15. PMID 27516442, Free PMC Article
  5. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables adrenomedullin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adrenomedullin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of heart rate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adrenomedullin a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326709.1 → NP_001313638.1  adrenomedullin a precursor

    Status: VALIDATED

    Source sequence(s)
    CU571259
    UniProtKB/TrEMBL
    A0A8M1P2W6, E7F5V1
    Related
    ENSDARP00000127991.1, ENSDART00000155954.2
    Conserved Domains (1) summary
    pfam00214
    Location:1 → 132
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    66874763..66876959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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