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G2E3 G2/M-phase specific E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 55632, updated on 3-Apr-2024

Summary

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Official Symbol
G2E3provided by HGNC
Official Full Name
G2/M-phase specific E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:20338
See related
Ensembl:ENSG00000092140 MIM:611299; AllianceGenome:HGNC:20338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHF7B; KIAA1333
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in apoptotic process and protein ubiquitination. Predicted to act upstream of or within blastocyst development; negative regulation of intrinsic apoptotic signaling pathway; and protein polyubiquitination. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.4) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
14q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (30559158..30620064)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (24756977..24817883)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (31028364..31089270)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene G2E3 antisense RNA 1 Neighboring gene uncharacterized LOC105370432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8224 Neighboring gene SYF2 pre-mRNA splicing factor pseudogene 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:31090859-31092058 Neighboring gene sec1 family domain containing 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:31143443-31144642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8226 Neighboring gene NANOG hESC enhancer GRCh37_chr14:31161751-31162310 Neighboring gene ubiquitin conjugating enzyme E2 C pseudogene 1 Neighboring gene ribosomal protein L12 pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive analysis of the expression, prognostic significance, and regulation pathway of G2E3 in breast cancer. Shen Y, et al. World J Surg Oncol, 2022 Dec 15. PMID 36517818, Free PMC Article
  2. Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells. Schmidt F, et al. Oncotarget, 2015 Jan 20. PMID 25593194, Free PMC Article
  3. G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization. Brooks WS, et al. Exp Cell Res, 2007 Feb 15. PMID 17239372, Free PMC Article
  4. The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators. Crawford DF, et al. J Biol Chem, 2001 Oct 5. PMID 11483598
  5. G2E3 is a dual function ubiquitin ligase required for early embryonic development. Brooks WS, et al. J Biol Chem, 2008 Aug 8. PMID 18511420, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comprehensive analysis of the expression, prognostic significance, and regulation pathway of G2E3 in breast cancer.
    Title: Comprehensive analysis of the expression, prognostic significance, and regulation pathway of G2E3 in breast cancer.
  2. Results suggest that G2E3 is a molecular determinant of the DDR and cell survival.
    Title: Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells.
  3. Cell cycle phase-specific expression and highly regulated subcellular localization of G2E3 suggest a possible role in cell cycle regulation and the cellular response to DNA damage.
    Title: G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20333, KIAA1333

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
G2/M phase-specific E3 ubiquitin-protein ligase
Names
G2/M phase-specific HECT-type E3 ubiquitin transferase
G2/M-phase specific E3 ubiquitin ligase
PHD finger protein 7B
NP_001295026.1
NP_060239.2
XP_011535227.1
XP_011535228.1
XP_047287508.1
XP_047287509.1
XP_047287510.1
XP_047287511.1
XP_047287512.1
XP_047287513.1
XP_054232304.1
XP_054232305.1
XP_054232306.1
XP_054232307.1
XP_054232308.1
XP_054232309.1
XP_054232310.1
XP_054232311.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308097.2 → NP_001295026.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 5' coding region, which results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB037754, AK296872, AW963891, BC008436, BC040179, BM993069
    Consensus CDS
    CCDS76669.1
    UniProtKB/TrEMBL
    B4DL73, F5GX24
    Related
    ENSP00000391068.2, ENST00000438909.6
    Conserved Domains (4) summary
    smart00119
    Location:365 → 646
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd15496
    Location:186 → 239
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:1 → 81
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl00077
    Location:376 → 646
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. NM_017769.5 → NP_060239.2  G2/M phase-specific E3 ubiquitin-protein ligase isoform 1

    See identical proteins and their annotated locations for NP_060239.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB037754, AI432917, BM993069, DA491192
    Consensus CDS
    CCDS9638.1
    UniProtKB/Swiss-Prot
    Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3
    UniProtKB/TrEMBL
    G3V483
    Related
    ENSP00000206595.6, ENST00000206595.11
    Conserved Domains (3) summary
    cd15496
    Location:232 → 285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14 → 127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl27008
    Location:411 → 692
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    30559158..30620064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536926.3 → XP_011535228.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

    UniProtKB/TrEMBL
    G3V483
    Conserved Domains (4) summary
    smart00119
    Location:372 → 653
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd15669
    Location:14 → 127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl00077
    Location:383 → 653
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl22851
    Location:210 → 246
    PHD_SF; PHD finger superfamily

  2. XM_047431552.1 → XP_047287508.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X3

  3. XM_047431554.1 → XP_047287510.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X5

    Related
    ENSP00000497335.1, ENST00000648008.1

  4. XM_047431556.1 → XP_047287512.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X7

  5. XM_047431557.1 → XP_047287513.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X8

    UniProtKB/TrEMBL
    B4DIF9
    Related
    ENST00000544007.5

  6. XM_011536925.3 → XP_011535227.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

    See identical proteins and their annotated locations for XP_011535227.1

    UniProtKB/Swiss-Prot
    Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3
    UniProtKB/TrEMBL
    G3V483
    Related
    ENSP00000451653.1, ENST00000553504.5
    Conserved Domains (3) summary
    cd15496
    Location:232 → 285
    PHD_PHF7_G2E3_like; PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cd15669
    Location:14 → 127
    ePHD_PHF7_G2E3_like; Extended PHD finger found in PHD finger protein 7 (PHF7) and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)
    cl27008
    Location:411 → 692
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  7. XM_047431553.1 → XP_047287509.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X4

  8. XM_047431555.1 → XP_047287511.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    24756977..24817883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376330.1 → XP_054232305.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X2

  2. XM_054376331.1 → XP_054232306.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X3

  3. XM_054376333.1 → XP_054232308.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X5

  4. XM_054376335.1 → XP_054232310.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X7

  5. XM_054376336.1 → XP_054232311.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X8

    UniProtKB/TrEMBL
    B4DIF9

  6. XM_054376329.1 → XP_054232304.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X1

    UniProtKB/Swiss-Prot
    Q7L622, Q9BVR2, Q9H9E9, Q9NXC0, Q9P2L3

  7. XM_054376332.1 → XP_054232307.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X4

  8. XM_054376334.1 → XP_054232309.1  G2/M phase-specific E3 ubiquitin-protein ligase isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L622.1 GenPept UniProtKB/Swiss-Prot:Q7L622

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