U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ddx20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 [ Danio rerio (zebrafish) ]

Gene ID: 556273, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
ddx20provided by ZNC
Official Full Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-202
See related
Ensembl:ENSDARG00000061204 AllianceGenome:ZFIN:ZDB-GENE-030131-202
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gemin3; fb59a11; wu:fb16g08; wu:fb59a11; si:dkey-193l3.3; si:dkey-193l3.4
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Acts upstream of or within fin regeneration; liver regeneration; and neuromast regeneration. Predicted to be part of SMN complex. Is expressed in brain. Orthologous to human DDX20 (DEAD-box helicase 20). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ddx20 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (28243226..28259817, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (28224087..28240627, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137490329 Neighboring gene potassium voltage-gated channel, Shal-related subfamily, member 3 Neighboring gene inka box actin regulator 2 Neighboring gene RAP1A, member of RAS oncogene family a Neighboring gene leiomodin 1a (smooth muscle)

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation. Pei W, et al. NPJ Regen Med, 2020. PMID 32218991, Free PMC Article
  2. Processing of fish Ig heavy chain transcripts: diverse splicing patterns and unusual nonsense mediated decay. Quiniou SM, et al. Dev Comp Immunol, 2011 Sep. PMID 21168434
  3. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
  4. Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Iwanami N, et al. Cell Rep, 2016 Nov 22. PMID 27880902, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fin regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuromast regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spliceosomal snRNP assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SMN complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
probable ATP-dependent RNA helicase DDX20
Names
DEAD box protein 20
NP_001116795.1
XP_021333937.1
XP_068079068.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001123323.1 → NP_001116795.1  probable ATP-dependent RNA helicase DDX20

    Status: PROVISIONAL

    Source sequence(s)
    BX664742
    UniProtKB/Swiss-Prot
    P0C218
    UniProtKB/TrEMBL
    A0A8M1NG84, F1R1C1
    Related
    ENSDARP00000081471.6, ENSDART00000087037.6
    Conserved Domains (3) summary
    COG0513
    Location:54 → 525
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam00271
    Location:289 → 398
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:56 → 260
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    28243226..28259817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478262.2 → XP_021333937.1  probable ATP-dependent RNA helicase DDX20 isoform X1

    UniProtKB/Swiss-Prot
    P0C218
    UniProtKB/TrEMBL
    A0A8M9PQW1
    Related
    ENSDARP00000143528.2, ENSDART00000175701.2
    Conserved Domains (1) summary
    COG0513
    Location:54 → 526
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

  2. XM_068222967.1 → XP_068079068.1  probable ATP-dependent RNA helicase DDX20 isoform X1

    Related
    ENSDARP00000118603.2, ENSDART00000134226.4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C218.1 GenPept UniProtKB/Swiss-Prot:P0C218

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.