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dyrk1b dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B [ Danio rerio (zebrafish) ]

Gene ID: 556212, updated on 2-Nov-2024

Summary

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Official Symbol
dyrk1bprovided by ZNC
Official Full Name
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-499
See related
Ensembl:ENSDARG00000070187 AllianceGenome:ZFIN:ZDB-GENE-060503-499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-225p5.1
Summary
Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within endoderm formation. Predicted to be active in nucleus. Is expressed in head and somite. Human ortholog(s) of this gene implicated in abdominal obesity-metabolic syndrome 3. Orthologous to human DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dyrk1b in Genome Data Viewer
Location:
chromosome: 16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (42070548..42152140, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (42120516..42203393, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 3d tandem duplicate 2 Neighboring gene zona pellucida glycoprotein 3d tandem duplicate 1 Neighboring gene uncharacterized LOC110437998 Neighboring gene uncharacterized LOC137487962 Neighboring gene alkB homolog 8, tRNA methyltransferase Neighboring gene fibrillarin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1. Bhat N, et al. Cell Signal, 2022 Feb. PMID 34752933, Free PMC Article
  2. The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Glenewinkel F, et al. Sci Rep, 2016 Jun 16. PMID 27307198, Free PMC Article
  3. The zebrafish dyrk1b gene is important for endoderm formation. Mazmanian G, et al. Genesis, 2010 Jan. PMID 20014342, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1.
    Title: Dyrk1b promotes autophagy during skeletal muscle differentiation by upregulating 4e-bp1.
  2. Data reveal a role for dyrk1b in endoderm formation and craniofacial patterning in the zebrafish.
    Title: The zebrafish dyrk1b gene is important for endoderm formation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endoderm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity tyrosine-phosphorylation-regulated kinase 1B
Names
dual-specificity tyrosine-regulated kinase
NP_001161737.1
XP_005158271.1
XP_005158272.1
XP_005158273.1
XP_005158274.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168265.1 → NP_001161737.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B

    Status: VALIDATED

    Source sequence(s)
    BX649388, BX901899
    UniProtKB/TrEMBL
    A0A0R4II39, A0A8M1NVN1
    Related
    ENSDARP00000135231.1, ENSDART00000160950.2
    Conserved Domains (2) summary
    smart00220
    Location:111 → 438
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:100 → 443
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    42070548..42152140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158217.5 → XP_005158274.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

    See identical proteins and their annotated locations for XP_005158274.1

    UniProtKB/TrEMBL
    A0A8M2B4J7, D1L3Y5
    Related
    ENSDARP00000030868.8, ENSDART00000038748.10
    Conserved Domains (2) summary
    smart00220
    Location:111 → 431
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:100 → 436
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  2. XM_005158216.5 → XP_005158273.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

    UniProtKB/TrEMBL
    A0A8M2B4K6
    Conserved Domains (2) summary
    smart00220
    Location:111 → 438
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:100 → 443
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  3. XM_005158215.5 → XP_005158272.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

    UniProtKB/TrEMBL
    A0A8M2B4L1
    Conserved Domains (2) summary
    smart00220
    Location:186 → 506
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:175 → 511
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

  4. XM_005158214.5 → XP_005158271.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

    UniProtKB/TrEMBL
    A0A8M2B533
    Conserved Domains (2) summary
    smart00220
    Location:186 → 513
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:175 → 518
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
Nucleotide Protein Strain
Heading Accession and Version

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