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DOCK10 dedicator of cytokinesis 10 [ Homo sapiens (human) ]

Gene ID: 55619, updated on 5-Mar-2024

Summary

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Official Symbol
DOCK10provided by HGNC
Official Full Name
dedicator of cytokinesis 10provided by HGNC
Primary source
HGNC:HGNC:23479
See related
Ensembl:ENSG00000135905 MIM:611518; AllianceGenome:HGNC:23479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZIZ3; DRIP2; Nbla10300
Summary
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
Expression
Broad expression in spleen (RPKM 10.3), lymph node (RPKM 9.4) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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See DOCK10 in Genome Data Viewer
Location:
2q36.2
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (224765090..225042468, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (225247277..225524737, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (225629807..225907185, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373910 Neighboring gene uncharacterized LOC105373911 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17187 Neighboring gene coiled-coil domain containing 195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17188 Neighboring gene NANOG hESC enhancer GRCh37_chr2:225757327-225757953 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:225799160-225800136 Neighboring gene uncharacterized LOC124906121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12386 Neighboring gene microRNA 4439 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:225965176-225966375 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:225968140-225969339 Neighboring gene NANOG hESC enhancer GRCh37_chr2:226182976-226183547 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:226331677-226332177 Neighboring gene MPRA-validated peak4058 silencer Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 Neighboring gene MPRA-validated peak4060 silencer Neighboring gene MPRA-validated peak4061 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12387 Neighboring gene uncharacterized LOC105373914 Neighboring gene uncharacterized LOC107985992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10. Parrado A. Mol Biol Rep, 2020 Apr. PMID 32112301
  2. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. Alcaraz-García MJ, et al. Hum Immunol, 2011 Jul. PMID 21514340
  3. Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes. Yelo E, et al. Mol Immunol, 2008 Jul. PMID 18499258
  4. ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation. Shin S, et al. Proc Natl Acad Sci U S A, 2019 Feb 19. PMID 30728292, Free PMC Article
  5. DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells. Gadea G, et al. Curr Biol, 2008 Oct 14. PMID 18835169

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10.
    Title: Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10.
  2. we identified the transcription factor FoxO1 as a potential mediator of ERK2-induced EMT, and thus we investigated the mechanism by which ERK2 regulates FoxO1. Additionally, our analysis revealed that ERK2 induced the expression of Dock10, a Rac1/Cdc42 GEF, during EMT
    Title: ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation.
  3. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
    Title: Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.
  4. Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation.
    Title: DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
  5. Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells.
    Title: Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of dedicator of cytokinesis 10 (DOCK10) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781A1532

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in marginal zone B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dedicator of cytokinesis protein 10
Names
dopamine receptor interacting protein 2
zizimin3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034039.1 RefSeqGene

    Range
    5146..282524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290263.2 → NP_001277192.1  dedicator of cytokinesis protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001277192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2; also known as DOCK10.2) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a distinct start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC011739, DB128847, EU236710
    Consensus CDS
    CCDS74661.1
    UniProtKB/Swiss-Prot
    Q96BY6
    Related
    ENSP00000386694.3, ENST00000409592.7
    Conserved Domains (5) summary
    cd08697
    Location:665 → 854
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1690 → 2135
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:176 → 296
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:176 → 283
    PH; PH domain
    pfam11878
    Location:60 → 147
    DUF3398; Domain of unknown function (DUF3398)

  2. NM_001363762.1 → NP_001350691.1  dedicator of cytokinesis protein 10 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a distinct start codon, compared to variant 1. The resulting protein (isoform 3) is longer and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC011739, AC093806
    Consensus CDS
    CCDS86925.1
    UniProtKB/TrEMBL
    A0A2R8YD85
    Related
    ENSP00000493664.1, ENST00000645028.1
    Conserved Domains (4) summary
    cd08697
    Location:684 → 873
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1709 → 2154
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:195 → 315
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam11878
    Location:79 → 166
    DUF3398; Domain of unknown function (DUF3398)

  3. NM_014689.3 → NP_055504.2  dedicator of cytokinesis protein 10 isoform 1

    See identical proteins and their annotated locations for NP_055504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1; also known as DOCK10.1) encodes isoform 1.
    Source sequence(s)
    AB014594, AC011739, AC017095, CR749492, DN991477, EG328193, EG328223, EG328495, EG328518, EG328531, EG328562
    Consensus CDS
    CCDS46528.1
    UniProtKB/Swiss-Prot
    B3FL70, O75178, Q68DA4, Q96BY6, Q9NW06, Q9NXI8
    Related
    ENSP00000258390.7, ENST00000258390.12
    Conserved Domains (5) summary
    cd08697
    Location:671 → 860
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1696 → 2141
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:182 → 302
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:182 → 289
    PH; PH domain
    pfam11878
    Location:66 → 153
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    224765090..225042468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444930.1 → XP_047300886.1  dedicator of cytokinesis protein 10 isoform X15

  2. XM_047444929.1 → XP_047300885.1  dedicator of cytokinesis protein 10 isoform X14

  3. XM_047444922.1 → XP_047300878.1  dedicator of cytokinesis protein 10 isoform X7

  4. XM_047444921.1 → XP_047300877.1  dedicator of cytokinesis protein 10 isoform X6

  5. XM_047444918.1 → XP_047300874.1  dedicator of cytokinesis protein 10 isoform X3

  6. XM_047444928.1 → XP_047300884.1  dedicator of cytokinesis protein 10 isoform X13

  7. XM_047444927.1 → XP_047300883.1  dedicator of cytokinesis protein 10 isoform X12

  8. XM_047444926.1 → XP_047300882.1  dedicator of cytokinesis protein 10 isoform X11

  9. XM_047444919.1 → XP_047300875.1  dedicator of cytokinesis protein 10 isoform X4

  10. XM_017004447.2 → XP_016859936.1  dedicator of cytokinesis protein 10 isoform X2

  11. XM_047444925.1 → XP_047300881.1  dedicator of cytokinesis protein 10 isoform X10

  12. XM_047444923.1 → XP_047300879.1  dedicator of cytokinesis protein 10 isoform X8

  13. XM_006712617.5 → XP_006712680.1  dedicator of cytokinesis protein 10 isoform X1

    Conserved Domains (5) summary
    cd08697
    Location:684 → 873
    C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11699
    Location:1709 → 2154
    DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
    cd13267
    Location:195 → 315
    PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
    pfam00169
    Location:195 → 302
    PH; PH domain
    pfam11878
    Location:79 → 166
    DUF3398; Domain of unknown function (DUF3398)

  14. XM_047444932.1 → XP_047300888.1  dedicator of cytokinesis protein 10 isoform X17

  15. XM_047444931.1 → XP_047300887.1  dedicator of cytokinesis protein 10 isoform X16

  16. XM_047444924.1 → XP_047300880.1  dedicator of cytokinesis protein 10 isoform X9

  17. XM_047444920.1 → XP_047300876.1  dedicator of cytokinesis protein 10 isoform X5

  18. XM_047444936.1 → XP_047300892.1  dedicator of cytokinesis protein 10 isoform X21

  19. XM_047444934.1 → XP_047300890.1  dedicator of cytokinesis protein 10 isoform X19

  20. XM_047444933.1 → XP_047300889.1  dedicator of cytokinesis protein 10 isoform X18

  21. XM_047444935.1 → XP_047300891.1  dedicator of cytokinesis protein 10 isoform X20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    225247277..225524737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342856.1 → XP_054198831.1  dedicator of cytokinesis protein 10 isoform X15

  2. XM_054342855.1 → XP_054198830.1  dedicator of cytokinesis protein 10 isoform X14

  3. XM_054342848.1 → XP_054198823.1  dedicator of cytokinesis protein 10 isoform X7

  4. XM_054342847.1 → XP_054198822.1  dedicator of cytokinesis protein 10 isoform X6

  5. XM_054342844.1 → XP_054198819.1  dedicator of cytokinesis protein 10 isoform X3

  6. XM_054342854.1 → XP_054198829.1  dedicator of cytokinesis protein 10 isoform X13

  7. XM_054342853.1 → XP_054198828.1  dedicator of cytokinesis protein 10 isoform X12

  8. XM_054342852.1 → XP_054198827.1  dedicator of cytokinesis protein 10 isoform X11

  9. XM_054342845.1 → XP_054198820.1  dedicator of cytokinesis protein 10 isoform X4

  10. XM_054342843.1 → XP_054198818.1  dedicator of cytokinesis protein 10 isoform X2

  11. XM_054342851.1 → XP_054198826.1  dedicator of cytokinesis protein 10 isoform X10

  12. XM_054342849.1 → XP_054198824.1  dedicator of cytokinesis protein 10 isoform X8

  13. XM_054342842.1 → XP_054198817.1  dedicator of cytokinesis protein 10 isoform X1

  14. XM_054342858.1 → XP_054198833.1  dedicator of cytokinesis protein 10 isoform X17

  15. XM_054342857.1 → XP_054198832.1  dedicator of cytokinesis protein 10 isoform X16

  16. XM_054342850.1 → XP_054198825.1  dedicator of cytokinesis protein 10 isoform X9

  17. XM_054342846.1 → XP_054198821.1  dedicator of cytokinesis protein 10 isoform X5

  18. XM_054342862.1 → XP_054198837.1  dedicator of cytokinesis protein 10 isoform X21

  19. XM_054342860.1 → XP_054198835.1  dedicator of cytokinesis protein 10 isoform X19

  20. XM_054342859.1 → XP_054198834.1  dedicator of cytokinesis protein 10 isoform X18

  21. XM_054342861.1 → XP_054198836.1  dedicator of cytokinesis protein 10 isoform X20

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_017718.1: Suppressed sequence

    Description
    NM_017718.1: This RefSeq was permanently suppressed because it is a a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96BY6.3 GenPept UniProtKB/Swiss-Prot:Q96BY6

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