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KIF16B kinesin family member 16B [ Homo sapiens (human) ]

Gene ID: 55614, updated on 5-Mar-2024

Summary

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Official Symbol
KIF16Bprovided by HGNC
Official Full Name
kinesin family member 16Bprovided by HGNC
Primary source
HGNC:HGNC:15869
See related
Ensembl:ENSG00000089177 MIM:618171; AllianceGenome:HGNC:15869
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNX23; C20orf23; KISC20ORF
Summary
The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in adrenal (RPKM 10.5), colon (RPKM 7.0) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
20p12.1
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (16272104..16573448, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (16322635..16624561, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (16252749..16554093, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904874 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:16187279-16187780 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:16187781-16188280 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:16208020-16208897 Neighboring gene Sharpr-MPRA regulatory region 11342 Neighboring gene peptidylprolyl isomerase A pseudogene 17 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:16240179-16240692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17561 Neighboring gene Sharpr-MPRA regulatory region 7814 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12682 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr20:16417298-16418497 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:16456599-16456834 Neighboring gene Sharpr-MPRA regulatory region 3089 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59877 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:16553850-16554371 Neighboring gene uncharacterized LOC124904875 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59894 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIF16B is a candidate gene for a novel autosomal-recessive intellectual disability syndrome. Alsahli S, et al. Am J Med Genet A, 2018 Jul. PMID 29736960
  2. Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival. Yang S, et al. Int J Cancer, 2020 Jul 15. PMID 31618441, Free PMC Article
  3. The fusion of early endosomes induces molecular-motor-driven tubule formation and fission. Skjeldal FM, et al. J Cell Sci, 2012 Apr 15. PMID 22357949
  4. Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B. Hoepfner S, et al. Cell, 2005 May 6. PMID 15882625
  5. The structural basis of novel endosome anchoring activity of KIF16B kinesin. Blatner NR, et al. EMBO J, 2007 Aug 8. PMID 17641687, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells.
    Title: KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells.
  2. Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
    Title: Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
  3. KIF16B mutation is associated with autosomal-recessive intellectual disability syndrome.
    Title: KIF16B is a candidate gene for a novel autosomal-recessive intellectual disability syndrome.
  4. The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia.
    Title: The kinesin KIF16B mediates apical transcytosis of transferrin receptor in AP-1B-deficient epithelia.
  5. The tubule formations were dependent on microtubule interactions, and specifically controlled by Kif16b and dynein 1.
    Title: The fusion of early endosomes induces molecular-motor-driven tubule formation and fission.
  6. genome-wide significance in genes involved in synaptic signaling (KIF16B; p = 1.27E-08) and neurodevelopment (PAX5; p = 3.58E-08).
    Title: Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
  7. KIF16B, a kinesin-3, transports early endosomes to the plus end of microtubules in a process regulated by the small GTPase Rab5 and its effector.
    Title: Modulation of receptor recycling and degradation by the endosomal kinesin KIF16B.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum.
EBI GWAS Catalog
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.
EBI GWAS Catalog
Genome-wide association study of intelligence: additive effects of novel brain expressed genes.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,4-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables plus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables plus-end-directed microtubule motor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoderm development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in formation of primary germ layer ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
kinesin-like protein KIF16B
Names
kinesin motor protein
sorting nexin 23
testis secretory sperm-binding protein Li 201a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028043.2 RefSeqGene

    Range
    4987..306331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001199865.2 → NP_001186794.1  kinesin-like protein KIF16B isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AL049794, AL117376, AY166853, BC050577
    Consensus CDS
    CCDS82598.1
    UniProtKB/TrEMBL
    A0A1B0GTU3
    Related
    ENSP00000489838.1, ENST00000636835.1
    Conserved Domains (8) summary
    cd06874
    Location:1133 → 1260
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:597 → 1087
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:797 → 807
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:607 → 807
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001199866.2 → NP_001186795.1  kinesin-like protein KIF16B isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL049794, AL117376, AY166853, BC050577, BC150261
    Consensus CDS
    CCDS56178.1
    UniProtKB/Swiss-Prot
    Q96L93
    Related
    ENSP00000384164.1, ENST00000408042.5
    Conserved Domains (6) summary
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam09755
    Location:608 → 881
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    pfam13476
    Location:615 → 776
    AAA_23; AAA domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated

  3. NM_001410853.1 → NP_001397782.1  kinesin-like protein KIF16B isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL049794, AL117376, AL118509
    Consensus CDS
    CCDS93009.1
    UniProtKB/TrEMBL
    A0A1B0GVS8
    Related
    ENSP00000490639.2, ENST00000635823.2

  4. NM_024704.5 → NP_078980.3  kinesin-like protein KIF16B isoform 2

    See identical proteins and their annotated locations for NP_078980.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL049794, AL117376, AY166853, BC050577
    Consensus CDS
    CCDS13122.1
    UniProtKB/Swiss-Prot
    A6NKJ9, A7E2A8, B1AKG3, B1AKT7, C9JDN5, C9JI52, C9JSM8, C9JWJ7, Q2TBF5, Q5HYC0, Q5HYK1, Q5JWW3, Q5TFK5, Q86VL9, Q86YS5, Q8IYU0, Q96L93, Q9BQJ8, Q9BQM0, Q9BQM1, Q9BQM5, Q9H5U0, Q9HCI2, Q9NXN9
    UniProtKB/TrEMBL
    A0A140VK74
    Related
    ENSP00000347076.2, ENST00000354981.7
    Conserved Domains (8) summary
    cd06874
    Location:1184 → 1311
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:597 → 1081
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:797 → 807
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:607 → 807
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    16272104..16573448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440266.1 → XP_047296222.1  kinesin-like protein KIF16B isoform X13

  2. XM_047440264.1 → XP_047296220.1  kinesin-like protein KIF16B isoform X11

  3. XM_017027926.2 → XP_016883415.1  kinesin-like protein KIF16B isoform X9

    UniProtKB/Swiss-Prot
    Q96L93

  4. XM_047440262.1 → XP_047296218.1  kinesin-like protein KIF16B isoform X6

  5. XM_047440265.1 → XP_047296221.1  kinesin-like protein KIF16B isoform X12

  6. XM_047440263.1 → XP_047296219.1  kinesin-like protein KIF16B isoform X10

  7. XM_005260755.4 → XP_005260812.1  kinesin-like protein KIF16B isoform X8

    Conserved Domains (8) summary
    cd06874
    Location:1144 → 1271
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:608 → 1098
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808 → 818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618 → 818
    GBP_C; Guanylate-binding protein, C-terminal domain

  8. XM_006723588.4 → XP_006723651.1  kinesin-like protein KIF16B isoform X7

    Conserved Domains (8) summary
    cd06874
    Location:1178 → 1281
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:608 → 1092
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808 → 818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618 → 818
    GBP_C; Guanylate-binding protein, C-terminal domain

  9. XM_005260754.4 → XP_005260811.1  kinesin-like protein KIF16B isoform X5

    Conserved Domains (8) summary
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    COG0419
    Location:608 → 1092
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808 → 818
    GBP_C; coiled coil [structural motif]
    cl02563
    Location:1195 → 1292
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl20817
    Location:618 → 818
    GBP_C; Guanylate-binding protein, C-terminal domain

  10. XM_005260753.4 → XP_005260810.1  kinesin-like protein KIF16B isoform X4

    Conserved Domains (8) summary
    cd06874
    Location:1195 → 1322
    PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam09755
    Location:619 → 892
    DUF2046; Uncharacterized conserved protein H4 (DUF2046)
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808 → 818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618 → 818
    GBP_C; Guanylate-binding protein, C-terminal domain

  11. XM_047440261.1 → XP_047296217.1  kinesin-like protein KIF16B isoform X3

  12. XM_005260751.5 → XP_005260808.1  kinesin-like protein KIF16B isoform X2

    Conserved Domains (7) summary
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam13868
    Location:599 → 923
    TPH; Trichohyalin-plectin-homology domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:797 → 807
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:607 → 807
    GBP_C; Guanylate-binding protein, C-terminal domain

  13. XM_005260750.4 → XP_005260807.1  kinesin-like protein KIF16B isoform X1

    Conserved Domains (7) summary
    smart00129
    Location:3 → 365
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01365
    Location:2 → 365
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam00498
    Location:478 → 543
    FHA; FHA domain
    pfam13868
    Location:610 → 934
    TPH; Trichohyalin-plectin-homology domain
    pfam16183
    Location:364 → 476
    Kinesin_assoc; Kinesin-associated
    cd16269
    Location:808 → 818
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:618 → 818
    GBP_C; Guanylate-binding protein, C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    16322635..16624561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323646.1 → XP_054179621.1  kinesin-like protein KIF16B isoform X13

  2. XM_054323644.1 → XP_054179619.1  kinesin-like protein KIF16B isoform X11

  3. XM_054323642.1 → XP_054179617.1  kinesin-like protein KIF16B isoform X9

  4. XM_054323639.1 → XP_054179614.1  kinesin-like protein KIF16B isoform X6

  5. XM_054323645.1 → XP_054179620.1  kinesin-like protein KIF16B isoform X12

  6. XM_054323643.1 → XP_054179618.1  kinesin-like protein KIF16B isoform X10

  7. XM_054323641.1 → XP_054179616.1  kinesin-like protein KIF16B isoform X8

  8. XM_054323640.1 → XP_054179615.1  kinesin-like protein KIF16B isoform X7

  9. XM_054323638.1 → XP_054179613.1  kinesin-like protein KIF16B isoform X5

  10. XM_054323637.1 → XP_054179612.1  kinesin-like protein KIF16B isoform X4

  11. XM_054323636.1 → XP_054179611.1  kinesin-like protein KIF16B isoform X3

  12. XM_054323635.1 → XP_054179610.1  kinesin-like protein KIF16B isoform X2

  13. XM_054323634.1 → XP_054179609.1  kinesin-like protein KIF16B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96L93.2 GenPept UniProtKB/Swiss-Prot:Q96L93

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