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gramd1a GRAM domain containing 1A [ Danio rerio (zebrafish) ]

Gene ID: 555994, updated on 2-Nov-2024

Summary

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Official Symbol
gramd1aprovided by ZNC
Official Full Name
GRAM domain containing 1Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-688
See related
Ensembl:ENSDARG00000076689 AllianceGenome:ZFIN:ZDB-GENE-060503-688
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc88h04; si:ch211-225p5.11
Summary
Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1A (GRAM domain containing 1A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gramd1a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (41903173..41965222, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (41954990..42015285, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487852 Neighboring gene sodium channel, voltage-gated, type I, beta a Neighboring gene si:ch211-225p5.8 Neighboring gene PYD and CARD domain containing Neighboring gene caspase a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
  2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular sterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-plasma membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GRAM domain-containing protein 1A; protein Aster-A

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    41903173..41965222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214218.1 → XP_068070319.1  protein Aster-A isoform X1

  2. XM_021466992.2 → XP_021322667.1  protein Aster-A isoform X1

    UniProtKB/TrEMBL
    A0A8M9NZU2
    Conserved Domains (2) summary
    cd13220
    Location:239 → 332
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:535 → 682
    DUF4782; Domain of unknown function (DUF4782)

  3. XM_068214219.1 → XP_068070320.1  protein Aster-A isoform X2

  4. XM_068214220.1 → XP_068070321.1  protein Aster-A isoform X3

    Related
    ENSDARP00000120012.1, ENSDART00000142648.3
Nucleotide Protein Strain
Heading Accession and Version

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