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cps1 carbamoyl-phosphate synthase 1, mitochondrial [ Danio rerio (zebrafish) ]

Gene ID: 555623, updated on 18-Sep-2024

Summary

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Official Symbol
cps1provided by ZNC
Official Full Name
carbamoyl-phosphate synthase 1, mitochondrialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081105-17
See related
Ensembl:ENSDARG00000020028 AllianceGenome:ZFIN:ZDB-GENE-081105-17
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-225d17.3
Summary
Enables carbamoyl-phosphate synthase (ammonia) activity. Acts upstream of or within ammonium homeostasis and urea cycle. Predicted to be active in cytoplasm. Is expressed in ball; brain; liver; and muscle. Human ortholog(s) of this gene implicated in carbamoyl phosphate synthetase I deficiency disease; persistent fetal circulation syndrome; and vascular disease. Orthologous to human CPS1 (carbamoyl-phosphate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See cps1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (39027185..39138063)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (39217328..39327644)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496494 Neighboring gene myosin, light chain 1, alkali; skeletal, fast Neighboring gene receptor tyrosine-protein kinase erbB-4-like Neighboring gene erb-b2 receptor tyrosine kinase 4b Neighboring gene uncharacterized LOC108191338

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ontogeny of ornithine-urea cycle gene expression in zebrafish (Danio rerio). LeMoine CM, et al. Am J Physiol Regul Integr Comp Physiol, 2013 Jun 1. PMID 23576614
  2. Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase. Caldovic L, et al. PLoS One, 2014. PMID 24465614, Free PMC Article
  3. The African coelacanth genome provides insights into tetrapod evolution. Amemiya CT, et al. Nature, 2013 Apr 18. PMID 23598338, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables carbamoyl-phosphate synthase (ammonia) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbamoyl-phosphate synthase (ammonia) activity IEA
Inferred from Electronic Annotation
more info
  
enables carbamoyl-phosphate synthase (ammonia) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ammonium homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within urea cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbamoyl-phosphate synthase [ammonia], mitochondrial
Names
CPSIII
carbamoyl-phosphate synthetase 1
XP_683282.4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    39027185..39138063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_678190.9 → XP_683282.4  carbamoyl-phosphate synthase [ammonia], mitochondrial

    UniProtKB/TrEMBL
    A0A8N7TAJ3
    Related
    ENSDARP00000013089.9, ENSDART00000004742.11
    Conserved Domains (8) summary
    cd01744
    Location:209 → 385
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    smart01096
    Location:829 → 952
    CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
    cd01423
    Location:1350 → 1465
    MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
    TIGR01368
    Location:35 → 390
    CPSaseIIsmall; carbamoyl-phosphate synthase, small subunit
    TIGR01369
    Location:407 → 1467
    CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
    pfam00988
    Location:35 → 172
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
    pfam02786
    Location:536 → 738
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
    cl17255
    Location:1078 → 1279
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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