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dlec1 DLEC1 cilia and flagella associated protein [ Danio rerio (zebrafish) ]

Gene ID: 555583, updated on 27-Mar-2024

Summary

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Official Symbol
dlec1provided by ZNC
Official Full Name
DLEC1 cilia and flagella associated proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091204-65
See related
Ensembl:ENSDARG00000075825 AllianceGenome:ZFIN:ZDB-GENE-091204-65
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-246l21.2
Summary
Predicted to act upstream of or within negative regulation of cell population proliferation. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human DLEC1 (DLEC1 cilia and flagella associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See dlec1 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
38
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (20332979..20369622, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (20188565..20225186, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100334155 Neighboring gene mitogen-activated protein kinase kinase kinase 22 Neighboring gene acetyl-CoA acyltransferase 1 Neighboring gene phospholipase C, delta 1a Neighboring gene villin-like Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like a Neighboring gene microRNA 26a-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
deleted in lung and esophageal cancer protein 1
Names
deleted in lung and esophageal cancer 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    20332979..20369622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353955.2 → XP_017209444.1  deleted in lung and esophageal cancer protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M6Z474, E9QEP3
    Related
    ENSDARP00000112787.1, ENSDART00000143174.2

  2. XM_017353956.2 → XP_017209445.1  deleted in lung and esophageal cancer protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YWD1

  3. XM_678134.7 → XP_683226.4  deleted in lung and esophageal cancer protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8N7UUL3
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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